NFκB p65 Inhibitors
NFκB p65 inhibitors belong to a specific chemical class known for their ability to target and modulate the activity of the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) subunit p65. NFκB p65 is a crucial transcription factor that plays a central role in the regulation of various genes involved in inflammation, immune responses, cell survival, and proliferation. The inhibitors act by interfering with the activation or translocation of NFκB p65 to the cell nucleus, where it exerts its transcriptional control over target genes. These compounds can function through various mechanisms, such as preventing the phosphorylation of p65, blocking its interaction with other proteins or DNA. NFκB p65 inhibitors are designed with high selectivity and affinity for the p65 subunit, minimizing off-target effects. Their discovery and development have been driven by a growing understanding of the critical role of NFκB p65 in several diseases, including chronic inflammation, autoimmune disorders, and certain cancers.
By blocking the activity of this transcription factor, these inhibitors have the ability to modulate immune responses and inflammatory processes. Additionally, they may interfere with cell proliferation and survival pathways that rely on NFκB p65, presenting opportunities for further research and investigation in cellular biology and disease pathogenesis. Researchers are continually exploring the structure-activity relationships of NFκB p65 inhibitors to optimize their pharmacological properties, including potency, bioavailability, and metabolic stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is a well-known small molecule inhibitor of NFκB p65 activation. It prevents the degradation of IκBα, thereby inhibiting the nuclear translocation and transcriptional activity of p65. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Commonly found in the turmeric spice, curcumin exhibits anti-inflammatory properties by blocking the NFκB p65 signaling pathway. It inhibits the phosphorylation of IκBα, which leads to p65 retention in the cytoplasm and subsequent inhibition of target gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Found in red grapes and other plant sources, resveratrol has been shown to inhibit NFκB p65 activation by blocking the phosphorylation of IκBα, thereby impeding its degradation. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
This natural compound Found in Andrographis paniculata has been reported to inhibit NFκB p65 activation by preventing the nuclear translocation of p65. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Isolated from the medicinal herb Feverfew (Tanacetum parthenium), parthenolide effectively inhibits NFκB p65 by directly targeting IκB kinase (IKK) and preventing IκBα phosphorylation. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Commonly found in the roots of the Thunder God Vine (Tripterygium wilfordii), celastrol is a potent inhibitor of NFκB p65 activation. It disrupts the interaction between p65 and its co-activator CBP/p300. | ||||||
Tanshinone IIA | 568-72-9 | sc-200932 sc-200932A | 5 mg 25 mg | $88.00 $316.00 | 22 | |
Found in Salvia miltiorrhiza, tanshinone IIA suppresses NFκB p65 activation by blocking IκBα phosphorylation and degradation. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Commonly found in Withania somnifera (Ashwagandha), withaferin A inhibits NFκB p65 activation by blocking the nuclear translocation of p65. | ||||||
Z-Guggulsterone | 39025-23-5 | sc-204414B sc-204414 sc-204414A | 5 mg 10 mg 25 mg | $193.00 $369.00 $733.00 | 28 | |
Commonly found in the resin of the guggul tree (Commiphora wightii), guggulsterone inhibits NFκB p65 activation by suppressing the phosphorylation of IκBα. | ||||||
[6]-Shogaol | 555-66-8 | sc-473881 | 10 mg | $396.00 | ||
A bioactive compound found in ginger, 6-shogaol inhibits NFκB p65 activation by interfering with IκBα phosphorylation and subsequent proteasomal degradation. | ||||||