NF-1B Inhibitors
NF-1B inhibitors are a class of chemical compounds designed to target and modulate the activity of the NF-1B transcription factor. NF-1B, also known as nuclear factor kappa B, is a critical protein complex involved in the regulation of gene expression, immune responses, inflammation, and cell survival. It plays a pivotal role in maintaining cellular homeostasis by controlling the transcription of genes responsible for various cellular processes. In normal physiological conditions, NF-1B is tightly regulated and activated in response to specific signals such as cytokines, pathogens, and stressors. However, dysregulation of NF-1B activity is associated with numerous diseases, including cancer, autoimmune disorders, and chronic inflammation.
NF-1B inhibitors work by interfering with the signaling pathways that lead to NF-1B activation or by directly binding to the NF-1B complex itself. These inhibitors can modulate the activity of NF-1B by preventing its translocation to the nucleus, inhibiting its DNA binding capacity, or blocking its interactions with coactivators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
This commonly used non-steroidal anti-inflammatory drug (NSAID) inhibits NF-kappa B by suppressing the activation of Ikappa B kinase (IKK), a key upstream regulator of NF-kappa B. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Found in turmeric, curcumin is a natural compound that can inhibit NF-kappa B activation by blocking various signaling pathways involved in its activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
This polyphenolic compound, found in grapes and red wine, has anti-inflammatory properties and can inhibit NF-kappa B by modulating multiple molecular targets. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Used for inflammatory bowel disease, sulfasalazine inhibits NF-kappa B by blocking the synthesis of inflammatory mediators and suppressing IKK activity. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
CAPE, found in propolis, inhibits NF-kappa B by preventing the degradation of Ikappa B alpha, a protein that keeps NF-kappa B inactive in the cytoplasm. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
This natural compound from the Thunder God Vine inhibits NF-kappa B by disrupting the assembly of the IKK complex. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor used in cancer therapy, bortezomib indirectly inhibits NF-kappa B by preventing the degradation of Ikappa B alpha. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
A synthetic compound, Bay 11-7082 inhibits NF-kappa B by directly blocking the activation of IKK. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Initially developed as a sedative, thalidomide has immunomodulatory properties and can inhibit NF-kappa B by interfering with the degradation of Ikappa B alpha. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Found in the Andrographis paniculata plant, andrographolide inhibits NF-kappa B by interfering with IKK activity and Ikappa B alpha degradation. | ||||||