NF-1B inhibitors are a class of chemical compounds designed to target and modulate the activity of the NF-1B transcription factor. NF-1B, also known as nuclear factor kappa B, is a critical protein complex involved in the regulation of gene expression, immune responses, inflammation, and cell survival. It plays a pivotal role in maintaining cellular homeostasis by controlling the transcription of genes responsible for various cellular processes. In normal physiological conditions, NF-1B is tightly regulated and activated in response to specific signals such as cytokines, pathogens, and stressors. However, dysregulation of NF-1B activity is associated with numerous diseases, including cancer, autoimmune disorders, and chronic inflammation.
NF-1B inhibitors work by interfering with the signaling pathways that lead to NF-1B activation or by directly binding to the NF-1B complex itself. These inhibitors can modulate the activity of NF-1B by preventing its translocation to the nucleus, inhibiting its DNA binding capacity, or blocking its interactions with coactivators.
SEE ALSO...
Items 11 to 12 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Found in the feverfew plant, parthenolide inhibits NF-kappa B by targeting IKK and preventing nuclear translocation of NF-kappa B subunits. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
A flavonoid found in various plants, luteolin inhibits NF-kappa B by blocking IKK activation and reducing the nuclear translocation of NF-kappa B subunits. | ||||||