Neurobeachin Activators
Neurobeachin (NBEA) is a brain-specific protein implicated in the regulation of neuronal function and synaptic transmission. It is a large multidomain scaffolding protein that contains a BEACH domain, named after 'Beige and Chediak-Higashi,' which is involved in vesicle trafficking and signal transduction. Neurobeachin also has several other functional domains, including a coiled-coil region and a pleckstrin homology domain, suggesting a role in protein-protein interactions.
Neurobeachin is thought to be important for the proper targeting and anchoring of postsynaptic receptors, which are essential for the transmission of nerve impulses between neurons. It has been linked to the trafficking of AMPA-type glutamate receptors to synapses, a critical process for synaptic plasticity, learning, and memory.Mutations and deletions in the gene encoding Neurobeachin have been associated with autism spectrum disorders and intellectual disability, highlighting its significance in neurodevelopment and cognitive function. The protein is believed to influence the development and maturation of synapses, and disruptions in its expression or function can lead to neurological deficits.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin may increase Neurobeachin expression by elevating cAMP levels, which can activate PKA and modulate gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can regulate gene expression during neuronal differentiation, potentially affecting Neurobeachin levels. | ||||||
Potassium Chloride | 7447-40-7 | sc-203207 sc-203207A sc-203207B sc-203207C | 500 g 2 kg 5 kg 10 kg | $55.00 $155.00 $285.00 $455.00 | 5 | |
High KCl levels induce neuronal depolarization, which may enhance Neurobeachin expression as part of synaptic plasticity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium affects GSK-3 activity and Wnt signaling, which might influence Neurobeachin expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, by inhibiting HDAC, could potentially increase the expression of Neurobeachin. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) and could influence Neurobeachin expression through PKC-mediated signaling pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, an HDAC inhibitor, may enhance Neurobeachin expression through epigenetic modifications. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin might induce ER stress, leading to a cellular stress response that could upregulate Neurobeachin expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin, by altering intracellular calcium levels, may influence signaling pathways and affect Neurobeachin expression. | ||||||
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $109.00 $369.00 | 2 | |
NMDA receptor activation can modulate synaptic protein expression, potentially including Neurobeachin. | ||||||