Neuregulin-2 Activators
Neuregulin-2 Activators encompass a diverse array of chemical compounds that heighten the functional activity of Neuregulin-2 through discrete signaling pathways. The adenylate cyclase stimulant Forskolin, and the phosphodiesterase inhibitor IBMX, both elevate intracellular cAMP, which in turn activates PKA; this cascade can lead to the phosphorylation of proteins within the Neuregulin-2 signaling pathway, thereby amplifying Neuregulin-2's role in neuronal development and function. Neuregulin-2 activators are a collection of compounds that enhance the functional activity of Neuregulin-2 through specific and indirect mechanisms within various signaling pathways. Forskolin, known for its ability to raise cAMP levels, and IBMX, which prevents the breakdown of cAMP, both work to increase the activity of protein kinase A (PKA). This activation of PKA leads to subsequent phosphorylation events that can enhance the signaling milieu of Neuregulin-2, promoting its role in neuronal communication and growth. Moreover, the facilitation of intracellular calcium signaling through ionophores like Ionomycin and A23187 directly supports the calcium-dependent pathways that Neuregulin-2 may influence, leading to its enhanced functional activity.
Similarly, Epigallocatechin Gallate (EGCG) and Genistein, by modulating receptor tyrosine kinase activity, create a more favorable environment for Neuregulin-2 signaling by reducing competitive inhibition from other pathways. In addition, compounds like Sphingosine-1-phosphate and Anandamide, which engage with lipid signaling receptors, may potentiate the PI3K/AKT pathway, a known collaborator in the pathways influenced by Neuregulin-2, thus indirectly upregulating its activity. Activation of protein kinase C (PKC) by compounds such as PMA further provides phosphorylation cues to the Neuregulin-2 pathway. The strategic inhibition of PI3K by LY294002 and MEK by PD98059 may shift cellular signaling dynamics to favor the activation of parallel or compensatory pathways that involve Neuregulin-2, thereby promoting its role in cell signaling.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cAMP levels. Elevated cAMP activates PKA, leading to the phosphorylation of downstream targets that can include receptors and signaling proteins involved in the pathways that Neuregulin-2 is a part of, thus enhancing its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a potent antioxidant that inhibits several receptor tyrosine kinases and has been shown to influence signaling pathways associated with neuronal growth and development. This can enhance the activity of Neuregulin-2 by promoting the signaling environment it operates within. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate binds to its receptors, initiating a signaling cascade that can lead to the activation of the PI3K/AKT pathway, which is known to intersect with pathways that Neuregulin-2 is involved in, thereby enhancing its functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium can activate various calcium-dependent protein kinases, which may intersect with and activate signaling pathways directly involving Neuregulin-2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to an increase in cAMP levels. This can enhance the activity of Neuregulin-2 by indirectly stimulating the same signaling cascades as Forskolin, leading to potential phosphorylation of proteins in the Neuregulin-2 pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which plays a role in multiple signaling pathways. The activation of PKC can lead to the phosphorylation of proteins that are part of the pathways Neuregulin-2 is involved in, thereby enhancing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can increase the activation of alternative pathways when PI3K is inhibited, which might include pathways Neuregulin-2 is involved in, thereby indirectly enhancing its functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor which can lead to the activation of parallel signaling pathways that may be involved with Neuregulin-2, thereby potentially enhancing Neuregulin-2's activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a calcium ionophore, similar to Ionomycin, and enhances intracellular calcium, which can activate signaling pathways involving Neuregulin-2, thus increasing its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. By inhibiting competitive signaling pathways, it may enhance the functional activity of Neuregulin-2 through the reduction of negative regulatory effects on pathways Neuregulin-2 is involved in. | ||||||