NEDD1 Activators
NEDD1 Activators are a collection of chemical compounds that work to indirectly enhance the functional activity of NEDD1. This protein is a crucial component of γ-tubulin ring complexes (γ-TuRCs), which nucleate the growth of microtubules from the centrosome. NEDD1 Activators, such as paclitaxel and vinblastine, can influence microtubule dynamics. For example, paclitaxel stabilizes microtubules, impeding their depolymerization, which can indirectly enhance NEDD1's role in associating with γ-tubulin. On the other hand, vinblastine inhibits microtubule assembly, stimulating compensatory mechanisms that increase the function of NEDD1 as part of the γ-TuRCs.
Other NEDD1 Activators, such as colchicine, noscapine, and podophyllotoxin, bind to tubulin and alter its polymerization or conformation. This can influence NEDD1's function in the formation of γ-TuRCs and nucleation of microtubules. For instance, colchicine inhibits tubulin polymerization, indirectly enhancing NEDD1's role in microtubule nucleation. Furthermore, compounds like griseofulvin and estramustine can interact with microtubules and inhibit mitosis or microtubule assembly, respectively, enhancing NEDD1's role in spindle assembly. Lastly, monastrol, which inhibits the kinesin Eg5, can cause the collapse of the mitotic spindle, which can indirectly enhance NEDD1's function in spindle assembly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol (Paclitaxel) stabilizes microtubules and prevents their depolymerization. NEDD1 is known to associate with γ-tubulin, a protein crucial for microtubule nucleation. By stabilizing microtubules, paclitaxel can indirectly enhance the functional activity of NEDD1. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $109.00 $412.00 $561.00 $2244.00 | 9 | |
Vinblastine inhibits microtubule assembly. This opposite action to paclitaxel might stimulate compensatory mechanisms that increase the function of NEDD1 as part of the γ-tubulin ring complex formation. | ||||||
Noscapine | 128-62-1 | sc-219418 | 10 mg | $102.00 | ||
Noscapine binds to tubulin and alters its conformation, affecting microtubule dynamics. This can indirectly enhance NEDD1's function in γ-tubulin ring complex formation. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits microtubule assembly. This can indirectly enhance NEDD1's function in γ-tubulin ring complex formation and microtubule nucleation. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Combrestatin A4 binds to tubulin and inhibits its polymerization, indirectly enhancing NEDD1's function in γ-tubulin ring complex formation. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin interacts with microtubules and inhibits mitosis. This can indirectly enhance NEDD1's function in γ-tubulin ring complex formation and spindle assembly. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Estramustine binds to tubulin and inhibits microtubule assembly, indirectly enhancing NEDD1's function in γ-tubulin ring complex formation. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol inhibits microtubule polymerization, indirectly enhancing NEDD1's function in γ-tubulin ring complex formation. | ||||||
Dolastatin 10 | 110417-88-4 | sc-507413 | 5 mg | $980.00 | ||
Dolastatin 10 binds to tubulin and inhibits its polymerization, indirectly enhancing NEDD1's function in γ-tubulin ring complex formation. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits microtubule polymerization and causes microtubule sequestration, indirectly enhancing NEDD1's function in γ-tubulin ring complex formation. | ||||||