NBPF4 Inhibitors
NBPF4 inhibitors constitute a diverse class of compounds that modulate cellular signaling pathways crucial for NBPF4-related functions. These inhibitors act through distinct mechanisms, influencing NBPF4-associated cellular processes, including gene expression, proliferation, and differentiation.
Retinoic acid and ATRA, as vitamin A derivatives, bind to nuclear receptors, regulating gene transcription and influencing NBPF4-related pathways. Wortmannin and LY294002 inhibit PI3K, impacting downstream signaling pathways and potentially influencing NBPF4-related cellular processes. Trichostatin A and Vorinostat, as HDAC inhibitors, modulate chromatin structure, affecting the epigenetic landscape associated with NBPF4 functions.
SB 203580 and SP600125 selectively inhibit p38 MAPK and JNK, respectively, components of the MAPK pathway. These inhibitors influence NBPF4-associated pathways by preventing inhibitory signals transmitted through these kinases. PD98059 and U0126, selective MEK inhibitors, impact downstream signaling cascades, potentially influencing NBPF4-related cellular processes. 5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, modulates DNA methylation patterns, affecting the epigenetic environment associated with NBPF4 functions.
Collectively, NBPF4 inhibitors provide valuable tools for unraveling the intricate signaling networks and cellular processes regulated by NBPF4. Their specific mechanisms of action offer insights into the intricate molecular pathways underlying NBPF4 functions, shedding light on strategies targeting NBPF4-associated pathways in various physiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, binds to nuclear receptors, modulating gene transcription. It can influence NBPF4-related pathways by regulating the expression of genes involved in cellular processes. Retinoic acid may act as an indirect activator by promoting specific transcriptional changes associated with NBPF4 functions. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits phosphoinositide 3-kinase (PI3K), a key enzyme in the PI3K/Akt pathway. Inhibition of PI3K can impact downstream signaling pathways, potentially influencing NBPF4-related cellular processes. Wortmannin may act as an indirect activator by suppressing inhibitory signals, allowing activation of NBPF4-associated pathways that are regulated by the PI3K/Akt cascade. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor, affecting chromatin structure and gene expression. By inhibiting HDACs, it can modulate the epigenetic landscape, potentially influencing NBPF4-related pathways. Trichostatin A may act as an indirect activator by promoting a more permissive chromatin environment, facilitating the expression of genes associated with NBPF4 functions. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is a specific inhibitor of p38 mitogen-activated protein kinase (MAPK). Inhibition of p38 MAPK can impact downstream signaling cascades, potentially influencing NBPF4-related cellular processes. SB 203580 may act as an indirect activator by preventing inhibitory signals transmitted through the p38 MAPK pathway, allowing for the activation of NBPF4-associated pathways that intersect with this kinase. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits phosphoinositide 3-kinase (PI3K), a critical enzyme in the PI3K/Akt pathway. Inhibition of PI3K can influence downstream signaling pathways, potentially impacting NBPF4-related cellular processes. LY294002 may act as an indirect activator by suppressing inhibitory signals, allowing the activation of NBPF4-associated pathways that are regulated by the PI3K/Akt cascade. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is an HDAC inhibitor that alters chromatin structure and gene expression. By inhibiting HDACs, it can modulate the epigenetic landscape, potentially influencing NBPF4-related pathways. Vorinostat may act as an indirect activator by promoting a more permissive chromatin environment, facilitating the expression of genes associated with NBPF4 functions. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of c-Jun N-terminal kinase (JNK), a component of the MAPK pathway. Inhibition of JNK can impact downstream signaling cascades, potentially influencing NBPF4-related cellular processes. SP600125 may act as an indirect activator by preventing inhibitory signals transmitted through the JNK pathway, allowing for the activation of NBPF4-associated pathways that intersect with this kinase. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), a component of the MAPK pathway. Inhibition of MEK can influence downstream signaling cascades, potentially impacting NBPF4-related cellular processes. PD98059 may act as an indirect activator by preventing inhibitory signals transmitted through the MEK pathway, allowing for the activation of NBPF4-associated pathways that intersect with this kinase. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2'-deoxycytidine is a DNA methyltransferase inhibitor that affects DNA methylation patterns. By inhibiting DNA methylation, it can modulate the epigenetic landscape, potentially influencing NBPF4-related pathways. 5-Aza-2'-deoxycytidine may act as an indirect activator by promoting a more permissive DNA methylation environment, facilitating the expression of genes associated with NBPF4 functions. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1 and MEK2, components of the MAPK pathway. Inhibition of MEK can impact downstream signaling cascades, potentially influencing NBPF4-related cellular processes. U0126 may act as an indirect activator by preventing inhibitory signals transmitted through the MEK pathway, allowing for the activation of NBPF4-associated pathways that intersect with this kinase. | ||||||