NALP4C Activators
(NLR family, pyrin domain containing 4C) Activators consist of various small molecules, ions, and fatty acids that can modulate signaling pathways and cellular processes indirectly influencing the functionality of NALP4C. These activators do not directly bind to NALP4C but instead target upstream or parallel pathways that could result in an altered activity of the protein. For instance, compounds like Forskolin and Caffeine increase intracellular cAMP levels, which could enhance the function of ATP-binding proteins by impacting ATP-consuming kinases. Similarly, the calcium ionophore A23187 and BzATP can influence calcium-dependent and purinergic receptor-mediated inflammatory pathways, respectively, thereby indirectly modulating the activity of proteins associated with these responses.
Other compounds, including Resveratrol, Sulforaphane, and Curcumin, exert their effects by influencing cellular stress response pathways and inflammation regulation. Omega-3 fatty acids, which are components of cell membranes, play a role in modulating the composition and function of cellular membranes, potentially affecting the localization and function of membrane-associated proteins like NALP4C. These diverse chemical classes each interact with cellular pathways that either provide the second messengers necessary for NALP4C activation, alter the redox state of the cell to influence the protein's structure and function, or modify the lipid environment in which NALP4C operates. The precise molecular mechanisms by which these compounds may influence NALP4C activity will depend on the context of the signalling pathways involved and the current state of the cell, making their effects highly situation-dependent. Nevertheless, the common thread among these activators is their ability to induce changes in the cellular milieu that, in turn, can lead to the functional activation of NALP4C, despite the absence of direct binding interactions with the protein itself.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. The increase in calcium can modulate various calcium-dependent signaling pathways that could indirectly affect proteins involved in the inflammatory response, like NALP4C. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to an increase in cAMP levels. This can indirectly affect ATP-binding proteins by altering signaling pathways that involve cAMP and ATP consumption. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can modulate various signaling pathways, including sirtuins and AMPK, which are involved in cellular stress responses and inflammation. This modulation may indirectly affect the activity of ATP-binding proteins like NALP4C. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which plays a role in the cellular response to oxidative stress. This activation can indirectly influence proteins involved in inflammatory responses. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a substrate for sirtuins and PARPs, which are involved in DNA repair and cellular stress responses. By influencing these pathways, NAD+ can indirectly affect proteins that bind to ATP and are involved in inflammation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase-4 (PDE4), leading to increased cAMP levels. This change in cAMP can alter the activity of ATP-binding proteins indirectly by modifying cAMP-dependent signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin alters various signaling pathways, including NF-κB, which is a key regulator of the inflammatory response. Through these pathways, curcumin can indirectly influence proteins associated with ATP binding and inflammation. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
Omega-3 fatty acids can modulate inflammatory responses through their effects on the cell membrane composition and signaling pathways. This could indirectly affect the activity of ATP-binding proteins like NALP4C. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences several signaling pathways, including the inhibition of GSK-3β. This modulation can affect ATP-binding proteins indirectly by altering Wnt signaling and other pathways involved in the inflammatory response. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 is a lipid mediator that can modulate inflammation through its interactions with prostaglandin receptors. While it is a biological molecule, its signaling can indirectly affect proteins involved in ATP binding and inflammation. | ||||||