NALP4A Activators
NALP4A Activators represent a category of chemically diverse compounds that can elicit an indirect effect on the activation state or expression levels of the NALP4A protein. These substances typically exert their actions through the modulation of various cellular signaling pathways, rather than through direct interaction with the protein itself. Such pathways include those that regulate cyclic AMP (cAMP) levels, inflammatory mediators, and gene expression patterns, all of which may converge to influence the functionality of NALP4A. Compounds like forskolin and dibutyryl cAMP function by elevating intracellular cAMP, a second messenger that activates protein kinase A (PKA). PKA can phosphorylate numerous substrates, including transcription factors that may govern the transcriptional regulation of NALP4A or proteins that modulate its stability or activity. Similarly, caffeine acts as a phosphodiesterase inhibitor, leading to sustained cAMP levels and a prolonged PKA-mediated response. On the other hand, molecules such as curcumin and capsaicin may modulate NALP4A indirectly through their influence on cellular redox states and calcium signaling, respectively. These changes in cellular homeostasis can tweak inflammatory response pathways, potentially affecting NALP4A's role in such processes.
Resveratrol and retinoic acid are examples of activators that can impact gene expression via activation of specific protein deacetylases or nuclear receptors. These nuclear events can lead to alterations in the expression of genes, including those involved in inflammatory responses, where NALP4A is hypothesized to participate. Moreover, prostaglandin E2 operates through its receptors to modulate various aspects of cell signaling, which could lead to changes in NALP4A expression. Additionally, small molecules like spermine and nitric oxide donors can alter cellular functions through their roles in cellular signaling and modulation of immune responses, thereby creating an environment that can indirectly affect NALP4A activity. Collectively, NALP4A Activators do not represent a uniform chemical class but are instead a group of compounds that, through their distinct biochemical mechanisms, can create a cellular context conducive to the activation or upregulation of the NALP4A protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, a labdane diterpene compound, is known to activate adenylyl cyclase leading to an increase in cAMP levels. Elevated cAMP can enhance protein kinase A (PKA) activity, which may phosphorylate transcription factors or other proteins that could modulate the activity of NALP4A, especially if its function is regulated by cAMP-responsive elements. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
Dibutyryl cAMP is a cell-permeable cAMP analog. By mimicking cAMP, it can activate PKA, leading to downstream effects that might include the activation or increased expression of NALP4A through phosphorylation of relevant transcription factors or regulatory proteins. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is a phosphodiesterase inhibitor, which prevents the breakdown of cAMP in the cell, thereby potentially increasing cAMP levels. An increase in cAMP could indirectly enhance the activity of NALP4A by modifying signal transduction pathways that involve PKA, which in turn could influence NALP4A's activity or expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a biologically active polyphenolic compound found in turmeric. It has been shown to modulate various signaling pathways and could affect the expression of genes involved in inflammation. Although not directly activating NALP4A, it could alter the cellular environment in a way that modulates NALP4A activity or upregulates its expression. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin, the active component in chili peppers, is known to affect various cellular signaling pathways and could indirectly affect the activity of NALP4A through modulation of intracellular calcium levels or other signaling molecules that are part of the inflammatory response pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural phenol found in grapes. It is involved in the activation of SIRT1, a protein deacetylase, which can affect the function of transcription factors and other proteins. This indirect mechanism might influence the expression or activity of NALP4A. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium salicylate is a non-steroidal anti-inflammatory drug (NSAID). While its primary mode of action is inhibiting the enzyme COX, it also affects other inflammatory pathways. These effects could lead to alterations in NALP4A expression or function, given the protein's involvement in inflammatory responses. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is a GSK-3 inhibitor which may influence the Wnt signaling pathway. Though direct activation of NALP4A is not established, inhibiting GSK-3 could modify the cellular context in which NALP4A functions, potentially affecting its activity or expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is an active metabolite of vitamin A and impacts gene expression via its role as a ligand for nuclear receptors. This can lead to changes in the transcription of genes involved in inflammation, possibly influencing NALP4A function. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 is an inflammatory mediator that can modulate various cellular responses. It operates through G-protein-coupled receptors, potentially leading to changes in cAMP levels and PKA activity. This could have downstream effects on NALP4A activity or expression. | ||||||