NALP10 Activators
NALP10 Activators encompass a range of chemical compounds that indirectly stimulate NALP10's functional activity through various signaling pathways. Forskolin, for instance, by elevating intracellular cAMP levels, indirectly enhances NALP10's role by activating protein kinase A (PKA), which can phosphorylate substrates that may be part of the inflammatory and apoptotic processes involving NALP10. Resveratrol, by activating SIRT1, modulates NF-κB signaling, a key player in inflammation, which in turn could enhance NALP10's activity. Curcumin's inhibition of NF-κB might similarly influence NALP10's role in inflammatory pathways, while sulforaphane's activation of the Nrf2 pathway, a critical regulator of antioxidant response, could also indirectly augment NALP10 activity. Epigallocatechin gallate (EGCG) and quercetin, by modulating kinase activity and inhibiting PI3K/Akt signaling respectively, alter the cellular signaling landscape in a way that may enhance NALP10's function.
In addition, capsaicin's activation of TRPV1 and subsequent calcium influx could enhance NALP10 activity due to the role of calcium signaling in inflammation. Anakinra, by blocking IL-1 signaling, could shift inflammatory responses to pathways associated with NALP10. Rolipram's inhibition of PDE4 and the consequent increase in cAMP levels may similarly influence inflammatory signaling cascades and enhance NALP10 activity. Urolithin A, by inducing mitophagy, could affect cellular stress responses and potentially enhance NALP10's function. Nicotinamide mononucleotide (NMN), as a precursor in NAD+ biosynthesis, could influence sirtuins and metabolic pathways, indirectly affecting NALP10 activity. Lastly, Vitamin D3, through modulation of immune responses, may enhance NALP10 activity by affecting related immune signaling pathways. These diverse chemicals, via unique yet interconnected biological channels, serve to indirectly augment the activity of NALP10, highlighting their potential role in the modulation of NALP10's functional repertoire.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates the NF-κB pathway, which is involved in the immune response. By inhibiting this pathway, curcumin may enhance the activity of NALP10 by reducing the negative feedback regulation of inflammation, therefore potentially increasing the NALP10-mediated immune response. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1 which can modulate NF-κB activity. Through this modulation, resveratrol can enhance the activity of NALP10 by promoting a more regulated inflammatory response where NALP10 is involved. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $45.00 $60.00 $115.00 $170.00 $520.00 | 36 | |
Glyburide inhibits the NLRP3 inflammasome, which may lead to a compensatory enhancement of the NALP10 inflammasome as a result of inhibitory cross-talk or resource availability within the inflammasome pathways. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA modulates inflammatory processes by altering cell membrane fluidity and affecting signal transduction. By doing so, they can influence the activity of NALP10 by promoting an environment that favors its role in resolving inflammation. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin can activate TRPV1 channels leading to calcium influx, which could indirectly enhance NALP10 activity by altering inflammasome assembly or function through calcium-dependent signaling mechanisms. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin modulates several signaling pathways, including the inhibition of PI3K and PKC. This modulation can lead to an indirect enhancement of NALP10 activity by affecting pathways that regulate inflammation and NALP10's role in it. | ||||||