NAIF1 Inhibitors
Chemical inhibitors of NAIF1 can interact with various biochemical pathways to inhibit the function of this protein involved in apoptosis. Methylthiouracil disrupts thyroid hormone synthesis, which is integral to metabolic processes that affect cell survival, thus indirectly inhibiting NAIF1's function. Similarly, Chlorpromazine's antagonistic action on dopamine receptors can lead to the suppression of pro-apoptotic signals required by NAIF1 to execute its role in programmed cell death. Tamoxifen, by binding to estrogen receptors, modulates cell survival and death pathways, impacting NAIF1's regulatory functions in apoptosis.
Imatinib targets tyrosine kinases such as BCR-ABL, which are crucial in transmitting signals that may activate NAIF1. By blocking these kinases, Imatinib impedes the pathways that would otherwise facilitate NAIF1's involvement in apoptosis. LY294002 and Wortmannin both act as PI3K inhibitors, arresting the PI3K/AKT signaling pathway known to regulate cell survival, and thus can reduce the survival signals that NAIF1 requires to function. PD98059 and U0126, as inhibitors of MEK, affect the MAPK/ERK pathway, which also has a role in cell growth and survival, and their inhibitory action can lead to a decrease in signals promoting NAIF1's function in apoptosis. In the same vein, SB203580 and SP600125 target the p38 MAPK and JNK signaling pathways, respectively, which are implicated in stress responses and apoptosis regulation. By blocking these pathways, they can reduce the level of stress and apoptotic signals that NAIF1 utilizes. Rapamycin, an mTOR inhibitor, disrupts a pathway involved in cell growth and survival, potentially diminishing the growth and survival cues necessary for NAIF1's activity. Trichostatin A, differing from the others, inhibits histone deacetylases, thereby altering gene expression related to the cell cycle and apoptosis, which can impact NAIF1's role in these crucial cellular processes. Each inhibitor, through its unique mechanism, contributes to the modulation of NAIF1's activity in cell death regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Hydroxy-2-mercapto-6-methylpyrimidine | 56-04-2 | sc-238861 | 100 g | $111.00 | ||
Methylthiouracil is a thiourea derivative that can inhibit the function of NAIF1 by interfering with thyroid hormone synthesis. Since thyroid hormones regulate numerous metabolic processes, including those related to cell death and survival, the inhibition of thyroid hormone production can decrease metabolic activity, which is necessary for the function of NAIF1. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine, a phenothiazine derivative, can inhibit NAIF1 by antagonizing dopamine receptors. Dopamine signaling has been implicated in modulating apoptosis, and by inhibiting this signaling, Chlorpromazine may reduce the pro-apoptotic signals that NAIF1 requires for its function, thereby functionally inhibiting NAIF1. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen, a selective estrogen receptor modulator, can inhibit NAIF1 by binding to estrogen receptors, which play a role in cell survival and death pathways. By modulating these pathways, Tamoxifen can lead to the functional inhibition of NAIF1, which is involved in apoptosis. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a tyrosine kinase inhibitor that can inhibit NAIF1 by blocking the BCR-ABL kinase and other tyrosine kinases. By inhibiting these kinases, Imatinib can disrupt downstream signaling pathways that are crucial for the apoptotic functions in which NAIF1 is involved, thus inhibiting the activity of NAIF1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can inhibit NAIF1 by blocking the PI3K/AKT signaling pathway. PI3K/AKT is known to regulate cell survival, and by inhibiting this pathway, LY294002 can decrease the survival signals that may be necessary for the activity of NAIF1 in apoptosis. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which can inhibit NAIF1 by blocking the MAPK/ERK pathway. Since the MAPK/ERK pathway is involved in cell growth and survival, inhibiting it with PD98059 can reduce the pro-survival signals that are necessary for NAIF1 function related to cell death regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can inhibit NAIF1 by inhibiting the p38 MAPK pathway, which is involved in stress responses, including apoptosis. By blocking this pathway, SB203580 can decrease the stress signals that may be necessary for the activity of NAIF1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor that can inhibit NAIF1 by blocking the PI3K/AKT signaling pathway, similar to LY294002. By inhibiting this pathway, Wortmannin can decrease the survival signals that may be necessary for the activity of NAIF1 in its role in the regulation of apoptosis. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2 and can inhibit NAIF1 by blocking the MAPK/ERK pathway. By inhibiting this pathway, U0126 can reduce the pro-survival signals that are necessary for the activity of NAIF1, thereby inhibiting its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which can inhibit NAIF1 by blocking the JNK signaling pathway. The JNK pathway is involved in regulating apoptosis, and by inhibiting this pathway, SP600125 can decrease the apoptotic signals that may be necessary for the activity of NAIF1. | ||||||