Naglt1c Inhibitors
Major facilitator superfamily domain containing 4B5 inhibitors, commonly referred to as Naglt1c inhibitors, are chemicals that affect the function of the Naglt1c protein, which is predicted to be involved in glucose transmembrane transporter activity. These inhibitors often function by either directly binding to the transport protein, thereby blocking glucose entry into the cell, or by modulating the signaling pathways that regulate the activity of glucose transporters.
The chemical class of Naglt1c inhibitors encompasses a broad range of compounds, including natural phenols like phloretin, flavonoids such as apigenin, quercetin, and myricetin, and the alkaloid berberine. These compounds can alter the glucose transport across cell membranes by targeting glucose transporter proteins or their regulatory mechanisms. Other molecules like WZB117, STF-31, and Fasentin are more specific in their action and have been developed to target glucose transporters with high affinity. Given the similarity in the functional domain of Naglt1c with known glucose transporters, it is plausible these inhibitors also affect Naglt1c. Flavonolignans such as silybin and curcuminoids like curcumin also play a role in this inhibition by modulating the cellular environment and metabolic pathways related to glucose uptake and transport. These inhibitors do not necessarily have to bind directly to Naglt1c to affect its function; their interference with glucose transport can be a result of their broader impact on cellular metabolism and signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $64.00 $255.00 | 13 | |
Phloretin is a dihydrochalcone, a type of natural phenol. It inhibits various glucose transporters, and while its specificity for Naglt1c is not established, it can interfere with glucose transport across membranes. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
WZB117 is a small molecule that inhibits glucose transporters, particularly GLUT1. It may impact Naglt1c if the protein has similar binding sites or transport mechanisms to those of known GLUTs. | ||||||
STF 31 | 724741-75-7 | sc-364692 | 10 mg | $187.00 | 3 | |
STF-31 is a compound that targets glucose transporters. It disrupts glucose uptake, which could affect Naglt1c functionality if it shares characteristics with sensitive glucose transporters. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavonoid found in many plants. It is known to interfere with various cellular processes and may affect glucose transport through its action on related signaling pathways. | ||||||
Fasentin | 392721-37-8 | sc-215012 sc-215012A | 5 mg 25 mg | $128.00 $449.00 | ||
Fasentin is a chemical compound that inhibits glucose uptake in cells by targeting glucose transporters. This compound could inhibit Naglt1c by preventing glucose transport. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone derived from soy products. It acts on multiple signaling pathways and could inhibit Naglt1c by modulating pathways that regulate glucose transport. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonol that has been shown to affect glucose transporter activity. Its inhibition potential on Naglt1c could be due to its effects on glucose transport mechanisms. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silybin is a flavonolignan from milk thistle. It may inhibit glucose transporters and potentially affect Naglt1c activity by altering glucose uptake. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin is a flavone that modifies various cellular functions, including those related to glucose transport. Its effects on Naglt1c could stem from these general actions. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is an isoquinoline alkaloid that impacts multiple cellular pathways. It may inhibit Naglt1c indirectly by altering the cellular environment related to glucose transport. | ||||||