NAGAT Activators
N-Acetylgalactosaminyltransferase (NAGAT) is a critical enzyme in the biosynthesis of blood group determinants, playing a pivotal role in the glycosylation processes that define the ABO blood group system. This enzyme is responsible for the transfer of N-acetylgalactosamine to the H antigen, forming the A antigen in individuals with blood type A. The expression of NAGAT, as with many genes, is subject to a complex interplay of regulatory mechanisms within the cell, governed by a network of signaling pathways, transcription factors, and epigenetic modifications. Understanding the precise molecular switches that control the expression of NAGAT could provide insights into the fundamental aspects of gene regulation and the intricate dance of enzymes and proteins that determine cellular function.
The interplay of various biochemicals that can potentially induce the expression of NAGAT reveals the intricate nature of cellular regulation. Compounds such as 5-Azacytidine and Trichostatin A have been shown to alter the epigenetic landscape, potentially leading to the upregulation of key genes by remodeling chromatin structure to a more transcriptionally active state. Other molecules like retinoic acid and beta-estradiol may bind to specific receptors that interact with DNA at promoter regions of target genes, including that of NAGAT, to enhance transcription. Additionally, intracellular messengers such as cAMP, modulated by agents like Forskolin, can activate signaling cascades that culminate in the activation of transcription factors. These transcription factors then bind to response elements in the NAGAT gene promoter, stimulating its expression. Furthermore, compounds such as Epigallocatechin gallate (EGCG) and Resveratrol are known for their roles in gene expression induction through pathways that converge on nuclear factors. These interactions underscore the complexity of gene expression control and the potentiality of diverse molecules to serve as activators in a cellular context, bringing to light the elaborate regulatory environment in which genes like NAGAT operate.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine may upregulate NAGAT by hypomethylation of its gene promoter, thereby enhancing transcriptional activity in hematopoietic cells where NAGAT is relevant. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could induce NAGAT expression by binding to retinoic acid receptors, which then interact with retinoic acid response elements in the promoter region of the NAGAT gene, initiating transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylase, Trichostatin A can facilitate a more open chromatin configuration around the NAGAT gene, increasing the accessibility for transcription factors and RNA polymerase, thus stimulating gene transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate may upregulate NAGAT by inhibiting enzymes that remove acetyl groups from histones, resulting in a less condensed chromatin structure and a consequent elevation in gene transcription levels. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin can stimulate NAGAT expression by elevating intracellular cAMP, which activates protein kinase A (PKA) and subsequently enhances the binding of CREB to the NAGAT gene promoter, leading to increased transcription. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol may increase NAGAT levels by estrogen receptor-mediated activation of transcription factors that bind to estrogen response elements adjacent to the NAGAT gene, promoting its expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA can stimulate NAGAT expression through the activation of protein kinase C, which may enhance the phosphorylation state of transcription factors that target the NAGAT promoter, leading to increased gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could increase NAGAT transcription by activating signaling pathways that converge on transcriptional activators of the NAGAT gene, thus promoting its expression in cells that are involved in antigen presentation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may induce NAGAT expression through the activation of sirtuins, which can lead to the deacetylation of histone proteins associated with the NAGAT gene, resulting in enhanced transcriptional activity. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol, through its hormonal action, can stimulate NAGAT expression by the vitamin D receptor-mediated activation of transcription factors that enhance NAGAT gene transcription in target tissues. | ||||||