N6AMT2 Activators
N6AMT2 activators encompass a diverse group of chemicals that indirectly influence the activity of N6AMT2, primarily through the modulation of DNA methylation patterns. DNA methylation, a key epigenetic mechanism, involves the addition of methyl groups to DNA, primarily at the 5th carbon of cytosine residues in the context of CpG dinucleotides. This process is crucial for various cellular processes, including gene expression regulation, imprinting, and X-chromosome inactivation. N6AMT2, specifically involved in adenine methylation, is part of this broader epigenetic regulatory framework.
The chemicals listed, such as 5-azacytidine, decitabine, and S-Adenosylmethionine, influence DNA methylation either by serving as methyl donors or by inhibiting the activity of DNA methyltransferases (DNMTs). For instance, nucleoside analogs like 5-azacytidine and decitabine are incorporated into DNA during replication and block the action of DNMTs, leading to hypomethylation of DNA. This hypomethylation can have various downstream effects on gene expression and chromatin structure, which could indirectly influence the activity of N6AMT2. Similarly, compounds like EGCG, curcumin, and resveratrol are known for their ability to modulate DNA methylation patterns, although their direct interactions with specific DNMTs, including N6AMT2, are not clearly established.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that inhibits DNA methyltransferases, potentially affecting N6AMT2 activity indirectly by altering overall DNA methylation patterns. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A deoxycytidine analog, like 5-azacytidine, it inhibits DNA methyltransferases, which could indirectly affect N6AMT2 activity. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
A common cosubstrate involved in methyl group transfers. As a methyl donor, it might indirectly influence N6AMT2 activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor, potentially altering N6AMT2 activity indirectly by modifying DNA methylation patterns. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $110.00 $193.00 $407.00 $628.00 | 1 | |
A local anesthetic that also acts as a DNA methyltransferase inhibitor, potentially affecting N6AMT2's role in DNA methylation. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
An antihypertensive drug that also serves as a DNA methyltransferase inhibitor, potentially influencing N6AMT2 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol found in green tea, known to modify DNA methylation patterns, potentially impacting N6AMT2 function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A component of turmeric, has been shown to alter DNA methylation, which might affect N6AMT2 activity. | ||||||