MYPT3 Inhibitors
MYPT3 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the MYPT3 protein. MYPT3, short for Myosin Phosphatase Target subunit 3, is a subunit of the protein phosphatase 1 (PP1) holoenzyme, which is a critical regulator of various biological functions. The underlying mechanism of MYPT3 inhibitors involves the disruption of the interaction between MYPT3 and other subunits or binding partners, ultimately leading to a modulation of the phosphatase activity of PP1. This biochemical interaction is essential for the regulation of the phosphorylation state of numerous proteins within cells, which in turn can affect various signaling pathways.
The development of MYPT3 inhibitors encompasses the synthesis of small molecules that can bind to the MYPT3 protein with high specificity. These compounds are typically identified and optimized through a combination of structure-based drug design and high-throughput screening techniques. The molecular design of MYPT3 inhibitors requires a profound understanding of the protein's structure and the key amino acid residues involved in the binding interface with PP1 or its regulatory proteins.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Serine/threonine phosphatase inhibitor that can elevate the phosphorylation level of myosin light chain. By inhibiting dephosphorylation, it may indirectly affect MYPT3's function in the myosin phosphatase complex. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Inhibitor of protein phosphatases 1 and 2A, preventing myosin light chain dephosphorylation. By doing so, it can indirectly modulate the activity of MYPT3 within the myosin phosphatase complex. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Inhibits protein phosphatases 1 and 2A. This inhibition can indirectly influence the role of MYPT3 in regulating myosin light chain phosphorylation. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Phosphodiesterase inhibitor leading to elevated cAMP levels, which activates PKA. PKA phosphorylation can inhibit myosin light chain phosphatase, potentially affecting the activity of MYPT3 within the complex. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibitor of Rho-associated protein kinase (ROCK). ROCK is known to phosphorylate and inhibit myosin phosphatase. By inhibiting ROCK, Y-27632 can affect the activity of the myosin phosphatase complex and potentially MYPT3. | ||||||
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $32.00 $85.00 $165.00 $248.00 $486.00 $910.00 | 5 | |
ROCK inhibitor that can indirectly modulate the myosin phosphatase complex's activity, thereby potentially affecting MYPT3's role within the complex. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Myosin II inhibitor that prevents actin-myosin interaction. While not directly targeting MYPT3, it affects the cellular process in which MYPT3 plays a role, potentially influencing the protein's activity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase, which phosphorylates the myosin light chain. By inhibiting the kinase, the downstream activity of the myosin phosphatase complex, and potentially MYPT3, can be influenced. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
PKA inhibitor. Since PKA phosphorylation can influence the myosin phosphatase complex, H-89 can potentially modulate the activity of MYPT3 in the complex. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
A bioactive lipid mediator that activates RhoA and ROCK. By influencing the RhoA/ROCK pathway, it can indirectly affect the myosin phosphatase complex and the activity of MYPT3. | ||||||