MYPT3 Activators
Chemical activators associated with MYPT3 are fundamentally linked to modulation of the actin cytoskeleton and protein phosphorylation states. Compounds such as Forskolin can elevate cAMP levels leading to activation of PKA, which in turn may phosphorylate regulators of PP1, impacting its activity balance with MYPT3. Additionally, okadaic acid and calyculin A act as phosphatase inhibitors, altering the phosphorylation landscape within the cell, which can inadvertently modify MYPT3 activity due to shifts in protein phosphatase interactions and functions.
On the other hand, the dynamic state of the actin cytoskeleton is influenced by compounds such as Y-27632, fasudil, and blebbistatin. These compounds, through their actions on Rho-kinase and myosin II ATPase, can lead to modifications in actin filament organization and myosin light-chain phosphorylation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylyl cyclase increasing cAMP levels, which can enhance PKA activity. PKA can phosphorylate proteins that regulate PP1, potentially affecting MYPT3. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits myosin II ATPase activity which may impact the actin cytoskeleton and associated signaling pathways involving MYPT3. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
Acts as a bioactive lipid mediator which may influence PP1 activity through sphingolipid signaling pathways, possibly impacting MYPT3. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments which can affect actin dynamics and potentially influence MYPT3 through changes in cytoskeletal regulation. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Disrupts actin polymerization and can affect actin cytoskeleton signaling pathways, indirectly influencing MYPT3 activity. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds actin monomers and prevents polymerization, impacting actin dynamics and potentially affecting signaling pathways related to MYPT3. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules which can impact cellular signaling and mechanics, thereby potentially influencing pathways associated with MYPT3. | ||||||