Myosin X Activators
Myosin X, a member of the myosin superfamily, is a motor protein primarily involved in intracellular transport and cellular motility processes. It plays a crucial role in the regulation of actin dynamics and cytoskeletal organization, particularly in the context of cell migration, adhesion, and filopodia formation. Myosin X has been implicated in various cellular functions, including axonal growth, neuronal development, and cancer metastasis, highlighting its significance in both normal physiological processes and pathological conditions.
Activation of Myosin X is a tightly regulated process that involves multiple signaling pathways and cellular cues. One of the key mechanisms of activation is through the phosphorylation of specific residues within the myosin X molecule, which modulates its enzymatic activity and interaction with actin filaments. Additionally, calcium ions have been shown to play a crucial role in activating myosin X, possibly through direct binding to the protein or indirect regulation of downstream signaling cascades. Moreover, post-translational modifications such as acetylation and methylation have been implicated in fine-tuning the activity of myosin X, highlighting the complexity of its regulatory mechanisms. Overall, the activation of myosin X represents a highly coordinated process involving the integration of various intracellular signals and biochemical modifications, ultimately leading to the dynamic regulation of cytoskeletal dynamics and cellular motility.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels in cells, which can enhance the ATPase activity of Myosin X, promoting its motor function and intracellular trafficking activities. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in the phosphorylation of Myosin X, leading to its activation and subsequent modulation of cell motility and filopodia formation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calmodulin-dependent kinase II (CaMKII). CaMKII phosphorylates proteins involved in actin cytoskeleton reorganization, indirectly enhancing Myosin X-driven processes. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, preventing dephosphorylation of Myosin light chains, which can indirectly maintain Myosin X in an active state, promoting its role in cellular dynamics. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cAMP analog that activates PKA. PKA can phosphorylate regulatory proteins in pathways involving Myosin X, leading to its enhanced activity in cellular transport and signaling. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a permeable cAMP analog, mimics cAMP effects, activating PKA which subsequently can phosphorylate components of the actin cytoskeleton, indirectly supporting Myosin X activation and function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can modulate signaling pathways involved in cell motility and actin filament organization, potentially supporting the functional activation of Myosin X through indirect mechanisms involving antioxidative and anti-inflammatory effects. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
ML-9 is an inhibitor of myosin light chain kinase (MLCK). Its indirect influence on Myosin X involves disrupting myosin light chain phosphorylation, potentially activating Myosin X by modulating the regulatory mechanisms that control the activity and contractility of Myosin X in the cellular context. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits ROCK, leading to decreased phosphorylation of myosin light chain and altered actin cytoskeleton dynamics. This can indirectly enhance Myosin X activity by affecting the substrate and environment Myosin X operates in. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML-141 is a selective inhibitor of Cdc42. Its indirect modulation of Myosin X involves inhibiting Cdc42, potentially activating Myosin X by disrupting downstream signaling pathways associated with Cdc42 and the regulatory role of Cdc42 in coordinating cellular processes linked to Myosin X functions. | ||||||