Myosin Ic Inhibitors
The class of Myosin Ic inhibitors encompasses a diverse array of chemicals targeting different aspects of cellular processes involving actin-myosin interactions. Blebbistatin directly inhibits myosin ATPase activity, disrupting the contractile function of Myosin Ic. ML-7 indirectly modulates Myosin Ic by inhibiting myosin light chain kinase (MLCK), impacting myosin light chain phosphorylation. CK-666 interferes with actin polymerization by inhibiting the Arp2/3 complex, indirectly disrupting Myosin Ic-mediated cytoskeletal dynamics. Y-27632 indirectly influences Myosin Ic by inhibiting Rho-associated protein kinase (ROCK), affecting actin-myosin contractility.
Latrunculin A and Cytochalasin D disrupt actin polymerization, indirectly influencing Myosin Ic by altering the actin cytoskeleton. Jasplakinolide stabilizes actin filaments, promoting the association of Myosin Ic with the actin cytoskeleton. NSC 23766 inhibits Rac1, indirectly modulating Myosin Ic-mediated contractility by regulating actin dynamics. CK-869 inhibits the Arp2/3 complex, interfering with Myosin Ic association with actin filaments. SMIFH2 inhibits formin-mediated actin polymerization, indirectly disrupting Myosin Ic-mediated cellular processes. Wiskostatin inhibits the Wiskott-Aldrich syndrome protein (WASP) family, indirectly modulating Myosin Ic function by interfering with actin cytoskeleton remodeling. The diverse mechanisms of these inhibitors provide valuable tools for investigating the intricate connections between cellular processes and Myosin Ic function, enhancing our understanding of the protein's role in cellular dynamics and motility.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin is a selective inhibitor of myosin II ATPase activity. It binds to the myosin ATPase pocket, preventing the ATP hydrolysis required for myosin II motor activity. This inhibition directly impacts the contractile function of myosin II, including Myosin Ic, leading to decreased actin-myosin interactions and impairing cellular motility and contractility. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
CK-666 is an inhibitor of the Arp2/3 complex, which plays a crucial role in actin polymerization. Myosin Ic interacts with actin filaments, and CK-666 inhibits the formation of branched actin networks by preventing Arp2/3-mediated actin nucleation. Consequently, CK-666 indirectly interferes with the association of Myosin Ic with actin filaments, disrupting cytoskeletal dynamics and impairing cellular processes dependent on Myosin Ic function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), a key regulator of the actin cytoskeleton. Myosin Ic interacts with actin filaments, and ROCK influences actin-myosin contractility. By inhibiting ROCK, Y-27632 indirectly modulates Myosin Ic function, disrupting actin-myosin interactions and impacting cellular processes dependent on myosin-mediated contractility. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A is a potent inhibitor of actin polymerization. Myosin Ic interacts with actin filaments, and Latrunculin A disrupts the assembly of actin filaments, indirectly impacting the association of Myosin Ic with the actin cytoskeleton. This disruption leads to alterations in cellular morphology and motility, affecting processes dependent on Myosin Ic-mediated actin dynamics. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D is a fungal metabolite that disrupts actin polymerization by binding to the fast-growing (barbed) end of actin filaments. Myosin Ic interacts with actin, and Cytochalasin D inhibits the formation of actin filaments, indirectly influencing Myosin Ic-mediated cellular processes by disrupting the actin cytoskeleton. This disruption alters cellular morphology, motility, and other functions dependent on the interaction between Myosin Ic and actin filaments. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide is a natural cyclic peptide that stabilizes actin filaments. Myosin Ic interacts with actin, and Jasplakinolide enhances actin polymerization and stabilizes actin filaments. This stabilization indirectly influences Myosin Ic-mediated cellular processes by promoting the association of Myosin Ic with the actin cytoskeleton. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $160.00 | ||
CK-869 is a selective inhibitor of the Arp2/3 complex, which plays a crucial role in actin polymerization. Myosin Ic interacts with actin filaments, and CK-869 inhibits the formation of branched actin networks by preventing Arp2/3-mediated actin nucleation. Consequently, CK-869 indirectly interferes with the association of Myosin Ic with actin filaments, disrupting cytoskeletal dynamics and impairing cellular processes dependent on Myosin Ic function. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is a small molecule that inhibits formin-mediated actin polymerization. Myosin Ic interacts with actin filaments, and SMIFH2 disrupts actin dynamics by inhibiting formin-dependent actin nucleation. This inhibition indirectly influences Myosin Ic-mediated cellular processes by disrupting the actin cytoskeleton, leading to alterations in cellular morphology, motility, and other functions dependent on the interaction between Myosin Ic and actin filaments. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Wiskostatin is an inhibitor of the Wiskott-Aldrich syndrome protein (WASP) family, which regulates actin polymerization. Myosin Ic interacts with actin filaments, and WASP family proteins are involved in actin cytoskeleton remodeling. By inhibiting WASP, Wiskostatin indirectly modulates Myosin Ic function, disrupting actin-myosin interactions and affecting cellular processes dependent on myosin-mediated contractility. | ||||||