Myosin Ic Activators
The class of Myosin Ic activators encompasses a diverse array of chemicals that modulate the function of Myosin Ic in cellular processes involving actin-myosin interactions. These activators act either directly on Myosin Ic or indirectly through signaling pathways that influence its function. ML-141 directly activates Rho family GTPases, Cdc42, and RhoA, respectively, enhancing actin-myosin interactions and promoting cellular processes such as cell motility and adhesion. 3-Deazaneplanocin A (DZNep), an SAHH inhibitor, indirectly activates Myosin Ic by increasing RhoA activity, providing insights into the role of RhoA in Myosin Ic-mediated cellular dynamics. Calyculin A and Phorbol 12,13-dibutyrate indirectly activate Myosin Ic through modulation of phosphorylation. Calyculin A, a PP1 and PP2A inhibitor, prevents Myosin Ic dephosphorylation, enhancing actin-myosin interactions and promoting cellular processes like cell contraction. Phorbol 12,13-dibutyrate activates PKC, leading to increased phosphorylation of Myosin Ic, influencing actin dynamics. Lysophosphatidic Acid (LPA) indirectly modulates Myosin Ic by activating RhoA through GPCR signaling, providing a tool to explore the impact of GPCR signaling on Myosin Ic function.
The class also includes activators influencing gene expression. Retinoic Acid indirectly modulates Myosin Ic by affecting gene transcription, providing a tool to study the impact of gene expression on Myosin Ic function and cellular dynamics. Thrombin, a protease, indirectly activates Myosin Ic by influencing actin dynamics through PAR1 signaling. These activators collectively contribute to our understanding of the intricate regulation of Myosin Ic in various cellular processes, offering valuable tools for researchers studying the role of Myosin Ic in cell motility, adhesion, and cytoskeletal rearrangements.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML-141 is a small molecule activator of the Rho family GTPase Cdc42. Myosin Ic interacts with actin filaments, and Cdc42 is involved in actin cytoskeleton remodeling. ML-141 activates Cdc42, leading to increased actin polymerization and promoting the association of Myosin Ic with actin filaments. This activation enhances cellular processes dependent on Myosin Ic-mediated actin dynamics, such as cell motility and cytoskeletal rearrangements. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor. Myosin Ic is regulated by phosphorylation, and Calyculin A indirectly activates Myosin Ic by preventing its dephosphorylation. This activation enhances Myosin Ic-mediated actin-myosin interactions, promoting cellular processes such as cell contraction and cytoskeletal rearrangements. Calyculin A provides a tool to study the impact of Myosin Ic phosphorylation on cellular dynamics. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
Phorbol 12,13-dibutyrate is an activator of protein kinase C (PKC), which phosphorylates and activates Myosin Light Chain Kinase (MLCK). Myosin Ic is regulated by MLCK-mediated phosphorylation. Phorbol 12,13-dibutyrate activates PKC, leading to increased phosphorylation of Myosin Ic, enhancing actin-myosin interactions. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA is a bioactive lipid that acts on G protein-coupled receptors, including LPA receptors. Myosin Ic is involved in actin filament interactions, and LPA activates downstream signaling pathways, such as the RhoA-ROCK pathway. LPA indirectly modulates Myosin Ic by activating RhoA, promoting actin-myosin interactions and enhancing cellular processes dependent on Myosin Ic-mediated contractility, such as cell migration and adhesion. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene activator of adenylate cyclase, leading to increased cAMP levels. Myosin Ic is regulated by phosphorylation, and cAMP activates protein kinase A (PKA), which phosphorylates Myosin Ic. Forskolin indirectly activates Myosin Ic by increasing cAMP levels, enhancing actin-myosin interactions. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is a selective inhibitor of myosin light chain kinase (MLCK), an enzyme that phosphorylates the myosin light chain, regulating myosin activity. ML-7 indirectly modulates Myosin Ic by preventing its phosphorylation, disrupting actin-myosin interactions. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a small molecule that activates RhoA, a key regulator of actin-myosin contractility. Myosin Ic interacts with actin filaments, and RhoA modulates actin-myosin interactions. Rho Activator II directly activates RhoA, enhancing actin-myosin contractility and promoting cellular processes dependent on Myosin Ic-mediated contractility, such as cell migration and adhesion. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is a derivative of vitamin A that regulates gene expression through retinoic acid receptors (RARs). Myosin Ic is involved in cellular processes influenced by gene expression. Retinoic Acid indirectly modulates Myosin Ic by affecting gene transcription, promoting or inhibiting factors that influence actin-myosin interactions. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin is a serine protease that activates proteinase-activated receptor 1 (PAR1) and downstream signaling pathways. Myosin Ic is involved in actin filament interactions, and thrombin activates pathways influencing actin dynamics. | ||||||