Myosin Ic Antibody (13): sc-136544

Myosin Ic Antibody (13) is a mouse monoclonal IgG1 kappa light chain antibody that detects Myosin Ic protein of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Myosin Ic antibody (13) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). Myosin Ic, also known as Myosin I beta, plays a critical role in cellular processes by facilitating transport of organelles and vesicles along actin filaments, which is essential for maintaining cellular organization and function. Myosin Ic is particularly important in specialized cells, such as vestibular hair cells, where Myosin Ic may contribute to rapid adaptation mechanisms necessary for hearing and balance. The interaction between Myosin Ic and actin is vital for various cellular movements, including cytokinesis and phagocytosis, underscoring Myosin Ic′s significance in both normal physiology and potential pathophysiological conditions. With an ability to bind to actin filaments, Myosin Ic is integral to dynamic reorganization of the cytoskeleton, which is crucial for processes such as cell migration and shape changes.

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Myosin Ic Antibody (13) References:

1. Myosin-1c, the hair cell's adaptation motor.  |  Gillespie, PG. and Cyr, JL. 2004. Annu Rev Physiol. 66: 521-45. PMID: 14977412
2. Myo1c is designed for the adaptation response in the inner ear.  |  Batters, C., et al. 2004. EMBO J. 23: 1433-40. PMID: 15014434
3. Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway.  |  Bose, A., et al. 2004. Mol Cell Biol. 24: 5447-58. PMID: 15169906
4. Expression of the unconventional myosin Myo1c alters sodium transport in M1 collecting duct cells.  |  Wagner, MC., et al. 2005. Am J Physiol Cell Physiol. 289: C120-9. PMID: 15716323
5. Axonal isoforms of myosin-I.  |  Lund, LM., et al. 2005. Biochem Biophys Res Commun. 330: 857-64. PMID: 15809075
6. Fast adaptation in vestibular hair cells requires myosin-1c activity.  |  Stauffer, EA., et al. 2005. Neuron. 47: 541-53. PMID: 16102537
7. Selective expression of myosin IC Isoform A in mouse and human cell lines and mouse prostate cancer tissues.  |  Ihnatovych, I., et al. 2014. PLoS One. 9: e108609. PMID: 25259793
8. Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin.  |  McIntosh, BB., et al. 2015. Curr Biol. 25: 523-9. PMID: 25660542
9. Chemomechanical regulation of myosin Ic cross-bridges: Deducing the elastic properties of an ensemble from single-molecule mechanisms.  |  Berger, F. and Hudspeth, AJ. 2017. PLoS Comput Biol. 13: e1005566. PMID: 28549064
10. The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation.  |  Ji, HH. and Ostap, EM. 2020. J Biol Chem. 295: 3749-3756. PMID: 31811090
11. Membrane-bound myosin IC drives the chiral rotation of the gliding actin filament around its longitudinal axis.  |  Sato, Y., et al. 2023. Sci Rep. 13: 19908. PMID: 37963943
12. Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells.  |  Skowron, JF., et al. 1998. Cell Motil Cytoskeleton. 41: 308-24. PMID: 9858156

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Myosin Ic Antibody (13) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-Myosin Ic Antibody (13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Myosin Ic Antibody (13) Specifications

Alternate Product Name: Myosin Ic

Product Clone Name: 13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 239-360 and 859-971

Epitope Target: Myosin Ic

Epitope Species: human

Product Reactivity/Detection: Myosin Ic

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for Myosin Ic Antibody (13): AC: Agarose, HRP: Horseradish Peroxidase