Date published: 2025-11-24

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Myf-5 Inhibitors

Myf-5, a member of the myogenic regulatory factor (MRF) family, stands as a pivotal player in the orchestration of myogenic differentiation-a complex process that gives rise to skeletal muscle. As a transcription factor, Myf-5 plays a central role in activating the expression of genes essential for myoblast determination and muscle development. Understanding the intricate regulatory mechanisms governing Myf-5 is crucial for deciphering the molecular intricacies underlying skeletal muscle formation. Two compounds, SB431542 and LY364947, take a direct approach by inhibiting TGF-β receptors. TGF-β signaling is intimately involved in myogenic differentiation, and these inhibitors act as molecular brakes, impeding the pathway and, consequently, modulating Myf-5 expression. Several chemicals act indirectly by modulating crucial signaling pathways. SP600125 and PD98059, inhibitors of JNK and MEK, respectively, navigate the intricate MAPK pathway. This indirect approach allows them to influence Myf-5 expression by altering the signaling cascade upstream. Wortmannin and Rapamycin, acting on the PI3K/Akt and mTOR pathways, respectively, showcase how the modulation of these pathways impacts Myf-5, elucidating the intricate web of signaling events shaping myogenic differentiation. Cisplatin and 5-Fluorouracil, DNA-damaging and antimetabolite agents, respectively, exert their influence on Myf-5 by perturbing genomic stability and nucleotide metabolism. These compounds showcase the genomic underpinnings of Myf-5 regulation, reflecting the dynamic interplay between DNA integrity and myogenic processes. Staurosporine, a broad-spectrum kinase inhibitor, and Niclosamide, a Wnt pathway modulator, navigate multiple pathways. They showcase the complex interconnectivity of cellular signaling networks, affecting Myf-5 indirectly by altering the cellular environment through their broad-ranging interactions. Dasatinib, targeting Src family kinases, provides a lens into the role of these kinases in shaping the cellular milieu relevant to Myf-5. Its indirect modulation highlights the intricate involvement of Src kinases in the regulatory network governing Myf-5 and myogenic differentiation. In summary, this diverse collection of Myf-5 inhibitors transcends the traditional boundaries of direct inhibition, offering a multifaceted exploration of the regulatory landscape governing myogenic differentiation. By dissecting the specific pathways and molecular interactions of each compound, researchers can unravel the nuanced intricacies of Myf-5 regulation, providing valuable insights into the fundamental processes shaping skeletal muscle development.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$80.00
$212.00
$408.00
48
(1)

TGF-β receptor inhibitor. By blocking TGF-β signaling, it indirectly affects Myf-5 expression. TGF-β is known to regulate myogenic differentiation, and inhibiting its receptor can modulate the cellular environment, influencing Myf-5 levels and myogenesis.

LY 364947

396129-53-6sc-203122
sc-203122A
5 mg
10 mg
$105.00
$153.00
4
(1)

Another TGF-β receptor inhibitor, disrupting the TGF-β pathway. This influences myogenic differentiation and indirectly inhibits Myf-5 expression. By impeding TGF-β signaling, LY364947 alters the cellular milieu, impacting the regulatory network that governs Myf-5 activity.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

JNK inhibitor. While not directly targeting Myf-5, SP600125 disrupts the JNK pathway. Myf-5 expression is influenced by JNK signaling, so inhibiting this pathway with SP600125 can indirectly modulate Myf-5 levels and alter the cellular context relevant to myogenesis.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

MEK inhibitor. Acting on the MAPK pathway, PD98059 indirectly impacts Myf-5. This compound hinders the activation of MEK, an upstream regulator of MAPK. As Myf-5 is influenced by the MAPK pathway, inhibiting MEK alters the signaling cascade, potentially downregulating Myf-5 expression.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

PI3K inhibitor. By targeting the PI3K/Akt pathway, Wortmannin indirectly modulates Myf-5. This compound impedes PI3K activity, influencing downstream signaling cascades that regulate Myf-5 expression. The inhibition of PI3K alters the cellular environment, impacting myogenic processes and Myf-5 levels.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

mTOR inhibitor. Indirectly affecting Myf-5, Rapamycin disrupts the mTOR pathway. As mTOR is involved in myogenic differentiation, inhibiting it alters the cellular context, influencing Myf-5 expression. Rapamycin can modulate the regulatory network governing myogenesis and Myf-5 activity.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

HDAC inhibitor. While not directly acting on Myf-5, Trichostatin A impacts the epigenetic regulation of genes, including those involved in myogenesis. By inhibiting HDAC, it alters chromatin accessibility, potentially affecting Myf-5 expression indirectly through epigenetic modifications.

Cisplatin

15663-27-1sc-200896
sc-200896A
100 mg
500 mg
$76.00
$216.00
101
(4)

DNA-damaging agent. Indirectly influencing Myf-5 by disrupting DNA integrity. Cisplatin induces DNA damage, activating cellular responses that may impact Myf-5 expression. The altered genomic landscape due to DNA damage can modulate the regulatory network governing Myf-5 and myogenic processes.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$36.00
$149.00
11
(1)

Antimetabolite affecting nucleotide synthesis. While not directly targeting Myf-5, 5-Fluorouracil disrupts nucleotide metabolism, potentially impacting cellular processes related to Myf-5 expression. The altered nucleotide pool can indirectly influence the regulatory network governing Myf-5 and myogenesis.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

Broad-spectrum kinase inhibitor. Indirectly influencing Myf-5 by targeting multiple signaling pathways. Staurosporine's broad kinase inhibition alters the cellular signaling milieu, potentially affecting Myf-5 expression indirectly. It modulates various pathways contributing to the regulatory network governing Myf-5.