MUP7 Activators
MUP7, a critical protein, plays a significant role in various cellular processes, particularly in modulating responses to specific signaling pathways and controlling gene expression. Its primary function is to contribute to cellular processes through its activation, facilitating downstream cellular responses. The activation of MUP7 is achieved through two primary mechanisms: direct activation and indirect activation via gene expression regulation.
Direct activation involves the phosphorylation of MUP7 by various kinases such as PKA, PKC, CaMKII, and MEK/ERK. These kinases directly modify MUP7's structure and function, leading to its functional activation within the cell. On the other hand, indirect activation occurs through the regulation of gene expression. Certain molecules can influence the transcription factors responsible for controlling MUP7's production, resulting in increased levels of the protein. This increased protein production subsequently contributes to the functional activation of MUP7, ensuring that it can effectively participate in cellular processes. Understanding the mechanisms of activation and the functions of MUP7 is crucial for gaining insights into the intricate signaling pathways that it is involved in and their impact on cellular responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a direct activator of protein kinase C (PKC). Activated PKC phosphorylates MUP7, resulting in its functional activation. This occurs through the PKC-mediated signaling pathway, without affecting gene expression. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 induces intracellular calcium release, leading to activation of the calcium-dependent protein kinase, CaMKII. CaMKII phosphorylates MUP7 directly, causing its functional activation via calcium signaling. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates MUP7 by binding to its adrenergic receptor. Receptor activation triggers the cAMP-PKA pathway, resulting in direct phosphorylation and functional activation of the protein without affecting gene expression. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin elevates intracellular calcium levels, activating CaMKII. This activated kinase directly phosphorylates MUP7, leading to its functional activation via the calcium-dependent pathway, independent of gene upregulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid directly binds to nuclear receptors, leading to the activation of specific transcription factors that control MUP7 gene expression. This results in increased protein levels and functional activation. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyric acid is an HDAC inhibitor, causing histone acetylation and chromatin remodeling. This leads to enhanced gene transcription of MUP7, resulting in increased protein production and functional activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP mimics cAMP, directly activating PKA. Activated PKA phosphorylates MUP7, leading to its functional activation through the cAMP-PKA pathway, without influencing gene expression. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin induces ER calcium release, activating CaMKII. This activated kinase directly phosphorylates MUP7, leading to its functional activation via the calcium-dependent pathway, independent of gene upregulation. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Calcitriol is a direct activator of vitamin D receptor (VDR), which regulates MUP7 gene expression. Activation of VDR by calcitriol increases the protein's expression levels and functional activation. | ||||||
6-Benzylaminopurine | 1214-39-7 | sc-202428 sc-202428A | 1 g 5 g | $20.00 $52.00 | ||
6-Benzylaminopurine acts as a cytokinin and stimulates the MEK/ERK signaling pathway. This pathway directly phosphorylates MUP7, leading to its functional activation without altering gene expression. | ||||||