MUP7 Inhibitors
Mup7, designated as Major Urinary Protein 7 in Mus musculus (house mouse), plays a pivotal role in the intricate olfactory processes essential for the species' communication and survival. Predicted to enable odorant binding activity and localized in the extracellular space, Mup7 stands as a critical component in the molecular repertoire facilitating the detection and interpretation of environmental cues. The expression of Mup7 in the liver further emphasizes its physiological significance, potentially linking its function to broader metabolic or signaling pathways. As a gene associated with odorant binding, Mup7 likely participates in the recognition and interpretation of chemical signals, contributing to the mouse's ability to navigate its environment, communicate with conspecifics, and engage in essential behaviors related to mating and territoriality.
The inhibition of Mup7 involves a strategic intervention into specific signaling pathways crucial for its predicted function. These pathways encompass GPCR signaling, Phospholipase C (PLC) signaling, the MAPK/ERK pathway, intracellular calcium homeostasis, PI3K/AKT signaling, and the Ras/Raf/MEK/ERK pathway, among others. The inhibitors identified in the table collectively disrupt these pathways, exerting their effects on Mup7 indirectly by influencing the molecular and cellular processes that govern its odorant binding activity. For instance, inhibitors targeting GPCR signaling disrupt the initial steps of odorant reception, while those affecting intracellular calcium homeostasis modify the cellular environment where Mup7 is active. The intricate interplay of these inhibitors provides a nuanced understanding of the complex regulatory mechanisms governing Mup7, shedding light on the gene's functional significance in the context of olfactory processes in house mice.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Inhibits GPCR signaling crucial for Mup7's predicted odorant binding activity. Pertussis Toxin disrupts GPCR signaling, indirectly inhibiting Mup7 in the extracellular space where the protein is active. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Blocks SERCA, affecting intracellular calcium homeostasis. Thapsigargin indirectly inhibits Mup7's odorant binding activity by influencing calcium-dependent signaling pathways in the extracellular space. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Inhibits the MAPK/ERK pathway crucial for odorant binding activity. U0126 disrupts this pathway, indirectly inhibiting Mup7 in the extracellular space where the protein is active. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Induces calcium influx by facilitating ion transport across the cell membrane. Ionomycin disrupts intracellular calcium homeostasis, indirectly inhibiting Mup7's odorant binding activity by influencing calcium-dependent signaling pathways in the extracellular space. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Specifically inhibits Rac1, a GTPase involved in cytoskeletal reorganization. NSC 23766 indirectly inhibits Mup7's odorant binding by affecting GTPase signaling in the extracellular space. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK in the MAPK/ERK pathway associated with Mup7. PD98059 disrupts this pathway, indirectly inhibiting Mup7 in the extracellular space where the protein is active. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K/AKT pathway associated with Mup7. LY294002 disrupts PI3K/AKT signaling, indirectly inhibiting Mup7 in the extracellular space where the protein is active. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Inhibits SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase), affecting intracellular calcium homeostasis. Indirectly inhibits Mup7's odorant binding activity by influencing calcium-dependent signaling pathways in the extracellular space. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Targets Matrix Metalloproteinases (MMPs), influencing Extracellular Matrix (ECM) remodeling. Indirectly inhibits Mup7's odorant binding by modulating ECM, impacting the extracellular space where the protein is predicted to be active. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
Targets Raf-1 kinase in the Ras/Raf/MEK/ERK pathway associated with Mup7. GW5074 disrupts this pathway, indirectly inhibiting Mup7 in the extracellular space where the protein is active. | ||||||