mucolipin 2 Inhibitors
Mucolipin 2 (TRPML2) inhibitors represent a class of chemical compounds that modulate the activity of TRPML2, a member of the transient receptor potential (TRP) ion channel family. TRPML2 is a calcium-permeable channel primarily localized in endosomal and lysosomal membranes, where it participates in the regulation of intracellular trafficking and ion homeostasis. Inhibitors of TRPML2 work by binding to the channel, altering its conformation, and preventing the flow of cations, especially calcium, through the channel's pore. This ion channel plays a significant role in maintaining cellular ion equilibrium, particularly in vesicular environments, and its inhibition can alter the dynamic processes of vesicular fusion, membrane trafficking, and endosomal-lysosomal signaling. By inhibiting TRPML2, researchers can observe its impact on key cellular processes like autophagy, exocytosis, and immune response regulation.
Structurally, TRPML2 inhibitors often possess characteristics that allow them to interact specifically with the ion channel's regulatory or pore regions, where they form stable interactions that block the channel's opening. Many of these inhibitors are small molecules designed to penetrate cellular compartments like lysosomes and endosomes where TRPML2 is concentrated. Researchers study TRPML2 inhibitors to explore how ion channels contribute to fundamental cell processes, such as calcium signaling pathways, intracellular vesicle formation, and the broader effects on cellular metabolism. Investigating the molecular mechanisms of TRPML2 inhibition also provides insights into broader areas of cellular physiology, including the role of ion channels in vesicular trafficking and how perturbations in these pathways may lead to observable changes in cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound could demethylate the mucolipin 2 gene promoter, leading to its transcriptional downregulation by allowing transcription factors to bind more readily and repress gene activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can increase histone acetylation, resulting in a less compact chromatin structure and the subsequent downregulation of mucolipin 2 gene transcription due to altered gene accessibility. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid may bind to retinoic acid response elements in the mucolipin 2 gene promoter, leading to a decrease in its expression through the recruitment of co-repressor complexes that silence gene activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which could downregulate mucolipin 2 expression as a secondary effect of altered cell growth signaling and protein synthesis pathways. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
By intercalating into DNA, Actinomycin D prevents the elongation step of RNA synthesis by RNA polymerase, resulting in the decreased synthesis of the mucolipin 2 mRNA transcript. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide blocks the translocation step in eukaryotic protein synthesis, potentially leading to feedback inhibition of mucolipin 2 mRNA transcription as part of a cellular response to protein synthesis inhibition. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine raises endosomal and lysosomal pH, which could disrupt the normal trafficking of transcription factors or other regulatory proteins involved in the expression of the mucolipin 2 gene. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid induces hyperacetylation of histones, which may repress mucolipin 2 gene expression by changing the accessibility of the promoter region to transcriptional repressors. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3, potentially leading to a decrease in mucolipin 2 expression by altering the expression of transcription factors that control the mucolipin 2 gene. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib disrupts proteasomal degradation, potentially leading to the accumulation of misfolded proteins and a cellular stress response that may include the downregulation of mucolipin 2 expression. | ||||||