mucolipin 2 Activators
Mucolipin 2, known scientifically as MCOLN2, is a protein encoded by the MCOLN2 gene and is part of the transient receptor potential (TRP) channel family. These channels are integral to various physiological processes such as ion homeostasis and intracellular signaling. Mucolipin 2 specifically has been implicated in the regulation of endosomal and lysosomal function, which are critical compartments within the cell for the sorting, degradation, and recycling of biological materials. The protein is thought to influence the trafficking of lipids and proteins within cells, and it plays a role in maintaining the delicate balance of ions, such as calcium and iron, across cellular membranes. Understanding the regulation of mucolipin 2 expression is an active area of research, as it holds keys to unraveling the complex network of cellular homeostasis and signaling pathways.
A variety of chemical compounds have been identified that could potentially serve as activators to induce the expression of mucolipin 2. These activators may interact with cellular mechanisms to upregulate the transcription of the MCOLN2 gene or enhance the stability and efficiency of the mucolipin 2 protein. For instance, some compounds may influence gene expression by altering the chromatin structure, thus making the DNA more accessible to the transcription machinery. Others might activate specific transcription factors that directly bind to the promoter region of MCOLN2, thereby driving its expression. Certain activators may also modulate intracellular signaling cascades that culminate in the transcriptional activation of mucolipin 2. Although these molecules are diverse in structure and origin-ranging from vitamins and dietary components to synthetic molecules-their potential to induce mucolipin 2 expression embodies the intricate interplay between environmental factors and genetic regulation. Understanding how these activators function at a molecular level is crucial for elucidating the physiological roles of mucolipin 2 and its involvement in cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may upregulate mucolipin 2 by binding to retinoic acid receptors, which then bind to DNA response elements and stimulate transcription. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Activation of the vitamin D3 receptor by Cholecalciferol could stimulate the expression of mucolipin 2 by promoting the binding of these receptors to vitamin D response elements in the gene's promoter region. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could stimulate the transcription of mucolipin 2 by inducing histone acetylation, thereby increasing gene accessibility to transcription factors. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin may upregulate mucolipin 2 by increasing intracellular cAMP levels, which in turn activates CREB, a transcription factor that can enhance mucolipin 2 gene transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may stimulate mucolipin 2 expression by inhibiting NF-κB, which can otherwise repress transcription, thus allowing for increased gene activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may induce mucolipin 2 expression by activating SIRT1, leading to the deacetylation of transcription factors that stimulate mucolipin 2 gene transcription. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may stimulate mucolipin 2 expression through the activation of the transcription factor NRF2, which can bind to antioxidant response elements in the promoter region of the gene. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin could induce mucolipin 2 expression by activating AMPK, which can phosphorylate and thereby activate transcription factors that stimulate the transcription of mucolipin 2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium may upregulate mucolipin 2 expression by inhibiting GSK-3, leading to enhanced activity of transcription factors that promote mucolipin 2 gene transcription. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone may increase mucolipin 2 expression by acting as a PPAR-γ agonist, which binds to PPAR response elements and stimulates the transcription of target genes including mucolipin 2. | ||||||