Mucin 2L inhibitors are a specific class of compounds that target the inhibition of Mucin 2 (MUC2), a key glycoprotein that is a major component of mucus in the gastrointestinal tract, especially in the intestines. MUC2 forms a protective mucus barrier over the epithelial lining of the intestines, playing a crucial role in defending the epithelial cells from harmful microorganisms, digestive enzymes, and mechanical damage. It is a gel-forming mucin, and its structure is characterized by extensive O-linked glycosylation, contributing to the viscoelastic properties of mucus. Mucin 2L inhibitors work by modulating the biosynthesis, secretion, or structural integrity of MUC2, thereby influencing the formation and stability of the mucus layer in experimental research settings.
Inhibitors of Mucin 2L are particularly valuable in studying the molecular mechanisms behind mucus production and secretion, as well as the factors that regulate MUC2 expression. By interfering with MUC2 function, researchers can investigate its role in maintaining intestinal homeostasis and its interactions with the gut microbiome. These inhibitors help unravel how MUC2 influences mucus barrier properties, the dynamics of epithelial cell protection, and the balance between immune defense and microbial colonization. Moreover, Mucin 2L inhibitors enable the exploration of the consequences of mucus layer disruption in various biological contexts, providing insights into the regulation of mucosal surfaces and the underlying pathways that control mucin expression. Through these investigations, Mucin 2L inhibitors contribute to a deeper understanding of mucosal biology and the molecular interplay between mucus and epithelial tissues.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
An antimetabolite that can reduce mucin production by inhibiting rapidly dividing cells, including mucosal epithelial cells. | ||||||
Prednisolone | 50-24-8 | sc-205815 sc-205815A | 1 g 5 g | $82.00 $248.00 | 2 | |
A corticosteroid that can modulate inflammation and potentially reduce mucin secretion in inflammatory conditions. | ||||||
Hyaluronic acid | 9004-61-9 | sc-337865 | 10 mg | $204.00 | ||
Although often used to promote hydration, in specific contexts, it can modulate mucin expression in epithelial tissues. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
An EGFR inhibitor that may affect mucin production, as EGFR signaling is involved in mucin regulation in epithelial cells. | ||||||
Budesonide | 51333-22-3 | sc-202980 sc-202980A sc-202980B sc-202980C | 50 mg 100 mg 200 mg 500 mg | $77.00 $88.00 $151.00 $343.00 | 3 | |
A glucocorticoid that can influence mucin production and secretion, particularly in the context of airway diseases. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
An inhibitor of N-linked glycosylation, potentially impacting the glycosylation status of mucins and their secretion. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A polyphenol that can modulate various signaling pathways, potentially influencing mucin production in epithelial cells. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Known for its anti-inflammatory properties, curcumin can influence mucin secretion and composition in epithelial cells. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
Used as a mucolytic agent, it can alter mucin properties and potentially affect mucin secretion. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Affects epithelial cell differentiation and may influence mucin gene expression and production. |