Date published: 2025-10-16

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Mucin 2L Inhibitors

Mucin 2L inhibitors are a specific class of compounds that target the inhibition of Mucin 2 (MUC2), a key glycoprotein that is a major component of mucus in the gastrointestinal tract, especially in the intestines. MUC2 forms a protective mucus barrier over the epithelial lining of the intestines, playing a crucial role in defending the epithelial cells from harmful microorganisms, digestive enzymes, and mechanical damage. It is a gel-forming mucin, and its structure is characterized by extensive O-linked glycosylation, contributing to the viscoelastic properties of mucus. Mucin 2L inhibitors work by modulating the biosynthesis, secretion, or structural integrity of MUC2, thereby influencing the formation and stability of the mucus layer in experimental research settings.

Inhibitors of Mucin 2L are particularly valuable in studying the molecular mechanisms behind mucus production and secretion, as well as the factors that regulate MUC2 expression. By interfering with MUC2 function, researchers can investigate its role in maintaining intestinal homeostasis and its interactions with the gut microbiome. These inhibitors help unravel how MUC2 influences mucus barrier properties, the dynamics of epithelial cell protection, and the balance between immune defense and microbial colonization. Moreover, Mucin 2L inhibitors enable the exploration of the consequences of mucus layer disruption in various biological contexts, providing insights into the regulation of mucosal surfaces and the underlying pathways that control mucin expression. Through these investigations, Mucin 2L inhibitors contribute to a deeper understanding of mucosal biology and the molecular interplay between mucus and epithelial tissues.

SEE ALSO...

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$36.00
$149.00
11
(1)

An antimetabolite that can reduce mucin production by inhibiting rapidly dividing cells, including mucosal epithelial cells.

Prednisolone

50-24-8sc-205815
sc-205815A
1 g
5 g
$82.00
$248.00
2
(1)

A corticosteroid that can modulate inflammation and potentially reduce mucin secretion in inflammatory conditions.

Hyaluronic acid

9004-61-9sc-337865
10 mg
$204.00
(0)

Although often used to promote hydration, in specific contexts, it can modulate mucin expression in epithelial tissues.

Gefitinib

184475-35-2sc-202166
sc-202166A
sc-202166B
sc-202166C
100 mg
250 mg
1 g
5 g
$62.00
$112.00
$214.00
$342.00
74
(2)

An EGFR inhibitor that may affect mucin production, as EGFR signaling is involved in mucin regulation in epithelial cells.

Budesonide

51333-22-3sc-202980
sc-202980A
sc-202980B
sc-202980C
50 mg
100 mg
200 mg
500 mg
$77.00
$88.00
$151.00
$343.00
3
(1)

A glucocorticoid that can influence mucin production and secretion, particularly in the context of airway diseases.

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$169.00
$299.00
66
(3)

An inhibitor of N-linked glycosylation, potentially impacting the glycosylation status of mucins and their secretion.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

A polyphenol that can modulate various signaling pathways, potentially influencing mucin production in epithelial cells.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Known for its anti-inflammatory properties, curcumin can influence mucin secretion and composition in epithelial cells.

N-Acetyl-L-cysteine

616-91-1sc-202232
sc-202232A
sc-202232C
sc-202232B
5 g
25 g
1 kg
100 g
$33.00
$73.00
$265.00
$112.00
34
(1)

Used as a mucolytic agent, it can alter mucin properties and potentially affect mucin secretion.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Affects epithelial cell differentiation and may influence mucin gene expression and production.