MTGR1 Inhibitors
MTGR1 inhibitors, as a chemical classification, encompass a diverse array of molecules that indirectly modulate the functions and activities of MTGR1, particularly its roles in transcriptional regulation, differentiation, and proliferation. This protein's involvement in corepressor complexes, particularly in the context of transcriptional repression and differentiation processes, underlines the significance of HDAC inhibitors in this category. Agents like Valproic acid, Trichostatin A, Vorinostat (Suberoylanilide Hydroxamic Acid), and Mocetinostat, by inhibiting HDACs, influence chromatin structure and accessibility. These changes in the chromatin landscape can subsequently modulate the transcriptional regulation activities associated with MTGR1.
DNA methylation, another key epigenetic mechanism, plays a fundamental role in governing transcriptional outcomes. By influencing this methylation, agents such as Zebularine, Decitabine, and 5-Azacytidine can indirectly affect the functions of MTGR1 in the broader context of transcriptional regulation. Another layer of complexity is added by BRD4 inhibitors like JQ1, I-BET762, and I-BET151. BRD4, involved in transcriptional elongation and regulation, can indirectly dictate MTGR1's role when its functions are tempered with these inhibitors.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
A histone deacetylase (HDAC) inhibitor. As MTGR1 works in a corepressor complex, inhibiting HDACs can indirectly influence MTGR1 function by modulating chromatin structure and transcriptional activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Another HDAC inhibitor that affects chromatin remodeling. By inhibiting HDACs, it indirectly modulates MTGR1's role in transcriptional repression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
An HDAC inhibitor that, by altering chromatin accessibility and structure, can influence MTGR1's corepressor functions indirectly. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Another agent targeting HDACs. Given MTGR1's association with corepressor complexes, HDAC inhibition can indirectly impact its function. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
An HDAC inhibitor that, by modulating the chromatin landscape, indirectly affects MTGR1-associated transcriptional regulation. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
A DNA methyltransferase inhibitor. By influencing DNA methylation patterns, it can indirectly modulate MTGR1-associated transcriptional activities. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Inhibits DNA methyltransferases. As DNA methylation can impact chromatin structure and accessibility, influencing MTGR1's corepressor functions indirectly. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Another DNA methyltransferase inhibitor. By affecting methylation, it indirectly influences MTGR1's transcriptional regulatory roles. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
It inhibits the bromodomain-containing protein 4 (BRD4), which plays a role in transcriptional regulation. Given MTGR1's involvement in transcriptional regulation, inhibiting BRD4 can indirectly influence MTGR1's function. | ||||||
GSK 525762A | 1260907-17-2 | sc-490339 sc-490339A sc-490339B sc-490339C sc-490339D | 5 mg 10 mg 50 mg 100 mg 1 g | $300.00 $540.00 $940.00 $1680.00 $5900.00 | ||
A BRD4 inhibitor. As BRD4 is involved in transcriptional elongation and regulation, inhibiting it can have secondary effects on MTGR1's function in the corepressor complex. | ||||||