MRTF-A Inhibitors
MRTF-A (Myocardin-related transcription factor A), also known as MAL or MKL1, is a member of the myocardin family of transcriptional coactivators. MRTF-A is a pivotal player in the regulation of gene expression in response to changes in actin dynamics within the cell. In its inactive state, MRTF-A is sequestered in the cytoplasm through binding to monomeric actin (G-actin). Upon specific cellular stimuli that lead to actin polymerization, MRTF-A is released from G-actin and translocates to the nucleus. Once in the nucleus, MRTF-A partners with serum response factor (SRF) to modulate the transcription of a plethora of genes, many of which are involved in cytoskeletal organization, cell motility, and differentiation. Given its central role in transducing signals from the cytoskeleton to the nucleus, the regulation of MRTF-A activity is crucial for various cellular processes and functions.
MRTF-A inhibitors are a class of chemical compounds designed to target and modulate the activity or function of MRTF-A. These inhibitors can function via several mechanisms. Some might prevent the nuclear translocation of MRTF-A by stabilizing its interaction with G-actin in the cytoplasm. Others might directly interfere with the MRTF-A/SRF interaction in the nucleus, hindering their combined transcriptional activity. Yet others could influence the post-translational modifications of MRTF-A, impacting its stability, localization, or interaction with partner proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CCG-1423 | 285986-88-1 | sc-205241 sc-205241A | 1 mg 5 mg | $30.00 $90.00 | 8 | |
CCG-1423 is a specific inhibitor of MRTF-A/SRF-mediated gene transcription. It impedes the nuclear accumulation of MRTF-A. | ||||||
CCG 203971 | 1443437-74-8 | sc-507360 | 10 mg | $89.00 | ||
CCG-203971 also inhibits MRTF-A/SRF-mediated gene transcription by blocking MRTF-A nuclear translocation. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filaments, increasing G-actin pools and preventing MRTF-A from translocating to the nucleus. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to G-actin and prevents F-actin polymerization, restricting MRTF-A nuclear translocation. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Simvastatin has been reported to suppress MRTF-A activity by inhibiting RhoA, a small GTPase that regulates MRTF-A. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor that can suppress MRTF-A nuclear translocation and activity by modulating the RhoA/ROCK pathway. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin inhibits myosin II ATPase activity and may indirectly affect MRTF-A nuclear accumulation. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
H-1152 is a potent inhibitor of Rho-kinase (ROCK), which can suppress MRTF-A by affecting the downstream pathway. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML7 inhibits myosin light chain kinase, impacting actin dynamics and potentially MRTF-A nuclear translocation. | ||||||
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $33.00 $87.00 $168.00 $253.00 $496.00 $910.00 | 5 | |
Fasudil is a ROCK inhibitor that can suppress the downstream effects on MRTF-A by modulating the RhoA/ROCK pathway. | ||||||