MRP7 Activators
The chemical class termed MRP7 Activators comprises compounds with the potential to modulate the activity of the Multidrug Resistance-Associated Protein 7 (MRP7), encoded by the MRP7 gene. While direct activators for MRP7 may not be explicitly identified, these compounds operate through various mechanisms, affecting pathways related to drug transport regulation and cellular processes influenced by MRP7. Activators of this class can potentially promote MRP7 by inducing the expression of transport proteins, including MRP7. In addition, activators may initiate MRP7 by upregulating the Nrf2-ARE signaling pathway, influencing cellular antioxidant responses.
MRP7 Activators can potentially activate MRP7 by modulating NF-κB signaling, and may activate MRP7 through pathways related to endothelin signaling. In addition, acitvators promote MRP7 by modulating PPAR-γ signaling and by influencing estrogen receptor signaling. These activators also promote MRP7 through pathways associated with PPAR-γ activation. Furthermore, activators may initiate MRP7 by modulating the PI3K/Akt signaling pathway and by modulating the MAPK/ERK signaling pathway. Lastly, activators of this class can potentially start MRP7 by influencing the Keap1-Nrf2-ARE pathway and by modulating the PI3K/Akt signaling pathway. MRP7 activators may promote MRP7 by modulating the Wnt/β-catenin signaling pathway. Collectively, these compounds showcase the potential diversity in mechanisms through which MRP7 Activators may impact MRP7 activity, offering insights into potential avenues for manipulating drug transport processes in various cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin can potentially activate MRP7 by inducing the expression of transport proteins, including MRP7. As a bactericidal antibiotic, rifampicin has been implicated in modulating drug transporters, and its impact on MRP7 expression suggests a mechanism for potential activation through increased expression and function. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane may activate MRP7 by upregulating the Nrf2-ARE signaling pathway. It enhances cellular antioxidant responses, potentially influencing MRP7 activity. The activation could occur through the Nrf2-ARE pathway's regulatory role in drug transporters, including MRP7. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can potentially activate MRP7 by modulating NF-κB signaling. NF-κB is involved in the regulation of drug transporters, and curcumin's impact on this pathway suggests a mechanism for indirect activation of MRP7. | ||||||
Bosentan | 147536-97-8 | sc-210957 | 10 mg | $195.00 | 3 | |
Bosentan, an endothelin receptor antagonist, may activate MRP7 through pathways related to endothelin signaling. Its influence on cellular processes associated with endothelin receptors suggests a potential mechanism for activating MRP7, although the details of this interaction require further investigation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may activate MRP7 by modulating PPAR-γ signaling. Its interaction with PPAR-γ, a nuclear receptor involved in drug transport regulation, suggests a potential avenue for indirect activation of MRP7. Resveratrol's impact on PPAR-γ could lead to changes in MRP7 expression and function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein can potentially activate MRP7 by influencing estrogen receptor signaling. Its interactions with estrogen receptors suggest a regulatory role in drug transporters, including MRP7. The modulation of estrogen receptor-related pathways may contribute to the activation of MRP7. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid can potentially activate MRP7 by modulating the PI3K/Akt signaling pathway. Its interactions with this pathway, known for its involvement in drug transport regulation, suggest a potential mechanism for indirect activation of MRP7. Betulinic acid's impact on PI3K/Akt signaling may influence MRP7 expression and function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin may activate MRP7 by modulating the MAPK/ERK signaling pathway. Its interactions with this pathway, implicated in drug transport regulation, suggest a potential mechanism for indirect activation of MRP7. Quercetin's impact on MAPK/ERK signaling may lead to changes in MRP7 expression and function. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic acid can potentially activate MRP7 by influencing the Keap1-Nrf2-ARE pathway. Its interactions with Nrf2-ARE signaling, known for its role in drug transport regulation, suggest a potential mechanism for indirect activation of MRP7. Oleanolic acid's impact on Nrf2-ARE signaling may contribute to changes in MRP7 expression and function. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $56.00 $180.00 | 8 | |
Ursolic acid may activate MRP7 by modulating the PI3K/Akt signaling pathway. Its interactions with this pathway, implicated in drug transport regulation, suggest a potential mechanism for indirect activation of MRP7. Ursolic acid's impact on PI3K/Akt signaling may lead to changes in MRP7 expression and function. | ||||||