MRP-L36 Activators
The activators of MRP-L36 engage in a variety of molecular mechanisms to enhance the protein's functional activity, particularly in the context of mitochondrial biogenesis and energy metabolism. For instance, certain activators target adenylate cyclase, either directly or via receptor-mediated signaling, leading to elevated levels of cAMP within the cell. This rise in cAMP triggers the activation of protein kinase A, a key regulator that can phosphorylate proteins involved in mitochondrial biogenesis. Consequently, this signaling cascade augments the production of mitochondrial proteins, including the mitochondrial ribosomal proteins like MRP-L36, to support the increased demand for mitochondrial translation capacity. Other activators work by modulating the AMP-activated protein kinase pathway, known for its role in cellular energy homeostasis. By stimulating this kinase, these activators promote the upregulation of mitochondrial biogenesis, thereby indirectly fostering the synthesis of mitochondrial components, of which MRP-L36 is a crucial part.
Alternatively, some activators exert their influence by interacting with metabolic regulators such as SIRT1 and PPAR-gamma. These interactions result in the deacetylation and activation of PGC-1α, a master regulator that orchestrates the increase in mitochondrial biogenesis. The resultant heightened production of mitochondrial proteins implicitly includes MRP-L36, which is essential for mitochondrial protein synthesis. Additionally, alterations in intracellular pH and energymetabolism by certain small molecules can indirectly necessitate the increased activity of mitochondrial ribosomal proteins. These molecules can induce metabolic changes that affect mitochondrial function, which may in turn stimulate the biogenesis of mitochondria and the associated ribosomal machinery. This adaptive response ensures that the cell's bioenergetics needs are met, which includes the proper functioning of mitochondrial ribosomes where MRP-L36 is integral.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly activates adenylyl cyclase, increasing intracellular cAMP levels. Increased cAMP enhances protein kinase A (PKA) activity, which can phosphorylate proteins involved in mitochondrial biogenesis, indirectly increasing MRP-L36 activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A non-selective beta-adrenergic receptor agonist that stimulates adenylyl cyclase through Gs protein coupling, leading to an increase in cAMP and activation of PKA, which may enhance mitochondrial protein synthesis including MRP-L36. | ||||||
Parathyroid hormone fragment (1-34) | 52232-67-4 | sc-487943 | 100 µg | $185.00 | ||
Activates the PTH receptor, ultimately increasing cAMP levels in osteoblasts. The activation of mitochondrial biogenesis by PKA could increase the demand for mitochondrial proteins such as MRP-L36. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates SIRT1, leading to deacetylation of PGC-1α, a master regulator of mitochondrial biogenesis. Activation of this pathway is likely to enhance the production and activity of mitochondrial proteins, including MRP-L36. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
Activates AMP-activated protein kinase (AMPK), promoting mitochondrial biogenesis and potentially increasing the synthesis of mitochondrial ribosomal proteins like MRP-L36 to meet the enhanced mitochondrial translation capacity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that directly activates PKA, leading to enhanced mitochondrial protein synthesis and potentially increasing the activity of mitochondrial ribosomal proteins, including MRP-L36. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
An adenosine A2B receptor agonist that increases intracellular cAMP levels, potentially enhancing PKA activity and the subsequent production of mitochondrial ribosomal proteins such as MRP-L36. | ||||||
Sodium bicarbonate | 144-55-8 | sc-203271 sc-203271A sc-203271B sc-203271C sc-203271D | 25 g 500 g 1 kg 5 kg 25 kg | $20.00 $28.00 $42.00 $82.00 $683.00 | 1 | |
Increases intracellular pH and can modulate cellular metabolism, potentially affecting mitochondrial function and increasing the need for mitochondrial ribosomal proteins, including MRP-L36. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
A PPAR-gamma agonist that promotes mitochondrial biogenesis, potentially enhancing the synthesis and function of mitochondrial ribosomal proteins including MRP-L36. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $253.00 | 1 | ||
Acts via the leptin receptor to promote alterations in energy metabolism that could necessitate enhanced mitochondrial protein synthesis, indirectly increasing the functional activity of MRP-L36 in the mitochondrial ribosome. | ||||||