MRP-L36 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
This compound inhibits eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, thus preventing the elongation of the polypeptide chain. This would lead to a reduction in the synthesis of MRP-L36 as it directly inhibits the function of the ribosome. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Binds to bacterial ribosomes and inhibits protein synthesis. In mitochondria, which have ribosomes similar to bacteria, chloramphenicol can inhibit mitochondrial protein synthesis, thus potentially decreasing the production of MRP-L36. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
Can bind to the 50S subunit of the bacterial ribosome, inhibiting protein synthesis. Through its action on mitochondrial ribosomes, erythromycin can inhibit the synthesis of mitochondrial proteins, potentially leading to a decrease in MRP-L36 levels. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
It binds to the 30S subunit of the bacterial ribosome, preventing attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site, inhibiting protein synthesis. As mitochondria have similar ribosomes to bacteria, tetracycline could inhibit the synthesis of mitochondrial proteins like MRP-L36. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $160.00 $319.00 | 3 | |
Acts as a peptide deformylase inhibitor. It inhibits the removal of N-formyl groups from nascent proteins, which is a critical step in bacterial and mitochondrial protein synthesis. This could lead to decreased synthesis of MRP-L36 by inhibiting its maturation process in the mitochondria. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Causes premature chain termination during translation by acting as an analog of aminoacyl-tRNA. Its effects on mitochondrial translation could lead to a reduction in the production of MRP-L36 by prematurely terminating its synthesis. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
Inhibits protein synthesis by binding to the 30S ribosomal subunit, blocking the binding of aminoacyl-tRNA to the A site of the ribosome. This action could decrease mitochondrial protein synthesis, subsequently reducing the production of MRP-L36. | ||||||
Azithromycin | 83905-01-5 | sc-254949 sc-254949A sc-254949B sc-254949C sc-254949D | 25 mg 50 mg 500 mg 1 g 5 g | $51.00 $101.00 $255.00 $357.00 $714.00 | 17 | |
Binds to the 50S ribosomal subunit, inhibiting mRNA translation. Its activity can extend to mitochondrial ribosomes, potentially reducing the production of MRP-L36. | ||||||
Tigecycline | 220620-09-7 | sc-394197 sc-394197A | 5 mg 25 mg | $186.00 $439.00 | 1 | |
A glycylcycline related to the tetracyclines. It inhibits protein synthesis by binding to the 30S ribosomal subunit and blocking entry of aminoacyl-tRNA molecules into the A site of the ribosome. This may affect mitochondrial protein synthesis and thus reduce the production of MRP-L36. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
This compound inhibits peptide chain elongation by specifically interfering with peptidyl transferase activity on ribosomes. Since this activity is crucial for protein synthesis, anisomycin's action would lead to a decrease in the synthesis of mitochondrial proteins, including MRP-L36, by disrupting mitochondrial ribosome function. | ||||||