MRG1 Activators
The chemical class known as MRG1 Activators encompasses a diverse array of compounds that exert their influence on MRG1, a protein involved in various cellular processes, through specific biochemical and cellular pathways. These compounds act as modulators, indirectly impacting MRG1 expression and function. Among these activators, retinoic acid, a well-known member of this class, stimulates the RAR/RXR pathway by binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), leading to the upregulation of MRG1 gene expression. Similarly, forskolin, another compound within this class, activates adenylate cyclase, elevating cyclic AMP (cAMP) levels and subsequently stimulating the PKA pathway. PKA, in turn, phosphorylates transcription factors, indirectly influencing MRG1 gene expression.
Furthermore, compounds like dexamethasone engage the glucocorticoid receptor (GR), leading to the modulation of target genes, including MRG1. Epigenetic modifiers such as 5-azacytidine can demethylate silenced gene promoter regions, reactivating MRG1. Additionally, MRG1 activators like valproic acid function as HDAC inhibitors, leading to histone acetylation and changes in MRG1 gene expression. This class of compounds represents a valuable toolkit for researchers studying the regulatory mechanisms of MRG1, as they can manipulate specific cellular pathways and processes that indirectly affect MRG1, shedding light on its role in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is known to activate the RAR/RXR pathway, which can lead to the upregulation of MRG1 expression. This activation occurs through binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), which subsequently modulate MRG1 gene transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can stimulate the PKA pathway, and PKA can phosphorylate transcription factors, which may influence MRG1 gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can activate the Wnt/β-catenin signaling pathway by inhibiting GSK-3β. Activation of this pathway can indirectly affect MRG1, as Wnt signaling interacts with various cellular processes, including gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate SIRT1, a NAD+-dependent deacetylase. SIRT1 activation can impact various cellular pathways, including those related to gene regulation, which may indirectly affect MRG1 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone can activate the glucocorticoid receptor (GR), leading to the modulation of various target genes. It can indirectly influence MRG1 expression by affecting the transcriptional activity of GR and its downstream targets. | ||||||
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $83.00 $272.00 | 1 | |
Lithocholic acid is an FXR agonist that can activate the FXR/RXR pathway. This activation can modulate MRG1 expression through the downstream effects of FXR on gene regulation and transcription. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane can activate the Nrf2/ARE pathway by stabilizing Nrf2 and promoting its nuclear translocation. Activation of Nrf2 can lead to the upregulation of MRG1 via antioxidant response element (ARE)-mediated gene transcription. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose can inhibit glycolysis, leading to increased AMP levels and activation of AMP-activated protein kinase (AMPK). AMPK activation can influence MRG1 indirectly through its effects on cellular energy homeostasis and gene regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can activate the Nrf2/ARE pathway by enhancing Nrf2 stability and nuclear translocation. This activation can impact MRG1 expression through the regulation of ARE-dependent gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can demethylate promoter regions, potentially leading to the reactivation of silenced genes. It could indirectly affect MRG1 expression by altering its epigenetic regulation. | ||||||