MR1 Inhibitors
MR1 inhibitors belong to a distinctive class of chemical compounds designed to modulate the activity of the MHC-related protein 1 (MR1). MR1 is a non-polymorphic major histocompatibility complex (MHC)-like molecule that plays a pivotal role in presenting metabolites found in microbial riboflavin biosynthesis to mucosal-associated invariant T (MAIT) cells. These T cells are a unique subset of immune cells that contribute to host defense against bacterial and fungal infections. MR1 inhibitors exert their pharmacological effects by interfering with the binding of small molecules to the MR1 protein, thereby disrupting the antigen presentation process. This disruption, in turn, influences the activation and response of MAIT cells, influencing the overall immune surveillance against microbial threats.
The development of MR1 inhibitors has garnered attention in the context of exploring novel avenues for immunomodulation. By targeting the MR1-dependent antigen presentation pathway, researchers aim to gain a deeper understanding of the intricate interplay between the immune system and microbial invaders. This class of compounds holds promise in unveiling new insights into the regulation of immune responses and could potentially contribute to the development of innovative strategies for bolstering the host's ability to combat infections. The exploration of MR1 inhibitors represents a significant step forward in deciphering the complexities of the immune system's recognition and response mechanisms, opening avenues for further research in the broader field of immunology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is a folate antagonist that can interfere with the folate pathway, which is involved in the production of proteins. This can indirectly inhibit MR1 by reducing the availability of proteins necessary for MR1's function. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an immunosuppressant that can inhibit the activity of T cells. As MR1 is involved in presenting antigens to T cells, inhibiting T cells can indirectly reduce the functional significance of MR1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Sirolimus inhibits mTOR, a kinase that is indirectly involved in protein synthesis regulation. By inhibiting protein synthesis, Sirolimus can indirectly affect the function of MR1. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, which are crucial for many cellular processes. By inhibiting these kinases, Staurosporine can indirectly impact the functioning of MR1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the SERCA pump, leading to an increase in cytosolic calcium concentration. This can indirectly affect MR1's stability and protein-protein interactions. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
Tacrolimus inhibits calcineurin, which is important in T cell activation. As MR1's function is related to T cell response, inhibiting these cells can indirectly reduce MR1's functional significance. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose inhibits glycolysis, a process that provides energy for various cellular functions. By disrupting energy availability, it can indirectly affect MR1's function. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal is a selective inhibitor of eIF2α dephosphorylation. By affecting protein synthesis, Salubrinal can indirectly influence MR1's function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A interferes with protein transport from the endoplasmic reticulum to the Golgi apparatus, which can indirectly impact the processing and presentation of antigens by MR1. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin binds to Hsp90 and interferes with its function, potentially affecting the correct folding and stability of proteins like MR1. | ||||||