MOSP Activators
MOSP, encoded by the PTPMT1 gene, is a pivotal protein located within the mitochondria, playing a crucial role in cellular energy metabolism and apoptosis regulation. The expression of MOSP is fundamental for maintaining mitochondrial integrity and facilitating apoptosis, processes integral to cellular health and homeostasis. While the regulatory mechanisms of MOSP expression are complex and multifaceted, research has unveiled that certain biochemical compounds can stimulate its transcriptional activity, thereby increasing its cellular levels. These activators can interact with various cellular pathways and influence gene expression by modifying the epigenetic landscape or by activating specific transcription factors that target the MOSP gene.
Compounds such as Retinoic Acid and Forskolin serve as examples of molecules that can potentially upregulate MOSP. Retinoic Acid, found in vitamin A, has been implicated in the differentiation of cells and may play a role in inducing MOSP expression as part of the differentiation process that necessitates robust mitochondrial function. Forskolin, through its elevation of cAMP, can activate a cascade that leads to the activation of transcription factors which may bind to the MOSP promoter region and enhance its expression. Other substances, including DNA methylation inhibitors like 5-Azacytidine, could promote MOSP expression by demethylating the gene promoter, thus permitting transcriptional machinery greater access to this region. Histone deacetylase inhibitors such as Trichostatin A (TSA) and Sodium Butyrate are also thought to be capable of facilitating MOSP transcription by altering chromatin structure around the MOSP gene, enabling a more transcriptionally active state. These biochemical activators, among others, demonstrate the diverse array of molecules that can play a role in modulating the expression levels of crucial mitochondrial proteins like MOSP, reflecting the intricate interplay between small molecule biochemistry and genetic regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid could upregulate MOSP expression as it is involved in mitochondrial function and biogenesis, which are processes that may be influenced by cellular differentiation and development, typically associated with retinoic acid signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin may stimulate the MOSP gene transcription by elevating cAMP levels, leading to a cascade of events activating transcription factors that target the MOSP gene's promoter region, thus enhancing its expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methylation, 5-Azacytidine could increase transcriptional activity of the MOSP gene by demethylating its promoter region, thereby facilitating the binding of transcription factors to initiate gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may stimulate MOSP expression by altering the acetylation status of histones associated with the MOSP gene, leading to a more open chromatin conformation and subsequent transcriptional activation of this gene. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride could enhance MOSP expression by inhibiting GSK-3 activity, potentially resulting in the activation of transcription factors that elevate MOSP gene expression due to the protein's role in mitochondrial function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate may upregulate MOSP expression through its HDAC inhibitory activity, leading to increased acetylation of histones near the MOSP gene and promoting an accessible chromatin state for transcription machinery. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate could stimulate MOSP expression by promoting antioxidant responses in cells, which could include the upregulation of genes involved in maintaining mitochondrial integrity and function, such as MOSP. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may induce MOSP expression by activating sirtuins, leading to downstream effects on mitochondrial function that may include induction of genes like MOSP, which play a role in the apoptotic process and mitochondrial maintenance. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin may upregulate MOSP expression by activating AMPK, a master regulator of cellular energy homeostasis, which may have downstream effects on mitochondrial biogenesis and function, processes in which MOSP is potentially involved. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone could induce MOSP expression by activating PPAR-gamma, a nuclear receptor that may upregulate genes involved in energy metabolism and mitochondrial function, potentially including MOSP. | ||||||