MOG Inhibitors
The inhibitors of MOG are compounds that may negatively influence the pathways related to the maintenance and integrity of the myelin sheath, or those that regulate immune responses within the CNS. These compounds can affect MOG either by directly leading to the degradation of the myelin sheath, where MOG is located, or by interfering with the cells responsible for myelin maintenance, the oligodendrocytes.
The hypothesized mechanisms of action for these inhibitors include the induction of demyelination through chemical or immune-mediated pathways, interference with the differentiation and proliferation of oligodendrocyte precursor cells, and the disruption of cellular signaling that supports myelin sheath integrity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Lysophosphatidylcholine (from egg yolk) | 9008-30-4 | sc-473611 sc-473611A sc-473611B sc-473611C | 25 mg 100 mg 500 mg 1 g | $87.00 $235.00 $607.00 $1102.00 | 1 | |
A lytic agent for myelin sheaths that could induce demyelination, potentially reducing the stability of MOG in the CNS. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
An immunosuppressant that may affect oligodendrocyte health, potentially leading to reduced MOG expression. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $48.00 $150.00 $588.00 $2086.00 | 12 | |
An intercalating agent that could disrupt DNA and potentially affect oligodendrocyte function, indirectly affecting MOG expression. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
An antimetabolite that could inhibit oligodendrocyte proliferation, potentially leading to decreased expression of MOG. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
An antineoplastic agent that could inhibit DNA synthesis, affecting oligodendrocyte proliferation and potentially MOG expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that can disrupt intracellular signaling and potentially affect oligodendrocyte health and MOG stability. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
An excitatory neurotransmitter that at high levels could induce excitotoxicity and CNS damage, potentially affecting MOG function. | ||||||