MOG Antibody (D-2): sc-376138
- MOG Antibody (D-2) is a mouse monoclonal IgG1 κ MOG antibody, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 223-257 within a C-terminal extracellular domain of MOG of human origin
- MOG Antibody (D-2) is recommended for detection of precursor and mature MOG of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, bovine and porcine
- Anti-MOG Antibody (D-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MOG Antibody (D-2) for WB and IHC(P) applications. These reagents are now offered in bundles with MOG Antibody (D-2) (see ordering information below).
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MOG Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects MOG protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MOG (D-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The myelin oligodendrocyte glycoprotein (MOG) plays a crucial role in the central nervous system by contributing to the formation and maintenance of the myelin sheath, which is essential for proper neuronal function and signal transmission. MOG is primarily located on the surface of oligodendrocytes and the outermost layers of mature myelin, where MOG facilitates cell adhesion and stabilizes microtubules within oligodendrocytes. MOG is a target for autoimmune responses that can lead to demyelination, significantly contributing to the pathology of multiple sclerosis (MS). Alternative splicing of MOG has resulted in the identification of various isoforms, which may have distinct functional roles in myelin biology and disease processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MOG Antibody (D-2) References:
- Myelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin. | 't Hart, BA. and Weissert, R. 2016. Mult Scler J Exp Transl Clin. 2: 2055217316630999. PMID: 28607715
- Myelin oligodendrocyte glycoprotein revisited-sensitive detection of MOG-specific T-cells in multiple sclerosis. | Bronge, M., et al. 2019. J Autoimmun. 102: 38-49. PMID: 31054941
- Myelin oligodendrocyte glycoprotein antibody-associated diffuse orbital inflammation. | Deschamps, R., et al. 2020. Mult Scler. 26: 1441-1443. PMID: 32539531
- Atypical Myelin Oligodendrocyte Glycoprotein Immunoglobulin G-Associated Disorder With Recurrent Meningoencephalitis. | Kim, JA. and Kim, SM. 2021. J Clin Neurol. 17: 610-613. PMID: 34595879
- Myelin Oligodendrocyte Glycoprotein Antibody-Mediated Optic Neuritis Following COVID-19 Vaccination. | Donaldson, LC. and Margolin, EA. 2023. J Neuroophthalmol. 43: e123-e125. PMID: 35234675
- Acute symptomatic seizures secondary to myelin oligodendrocyte glycoprotein antibody-associated disease. | Montalvo, M., et al. 2022. Epilepsia. 63: 3180-3191. PMID: 36168809
- Anaesthetic concerns in pregnancy associated with myelin oligodendrocyte glycoprotein encephalomyelitis. | Kuberan, A., et al. 2022. Indian J Anaesth. 66: 614-616. PMID: 36274798
- Dissection of complement and Fc-receptor-mediated pathomechanisms of autoantibodies to myelin oligodendrocyte glycoprotein. | Mader, S., et al. 2023. Proc Natl Acad Sci U S A. 120: e2300648120. PMID: 36943883
- Intravenous immunoglobulin treatment for acute attacks in myelin oligodendrocyte glycoprotein antibody disease. | Lotan, I., et al. 2023. Mult Scler. 29: 1080-1089. PMID: 37431144
- Deciphering the conformational dynamics of Myelin Oligodendrocyte glycoprotein in the myelin sheath. | Ananya, YK. and Ramya, L. 2024. J Biomol Struct Dyn. 1-8. PMID: 38910432
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MOG Antibody (D-2) | sc-376138 | 200 µg/ml | $322.00 | |||
MOG Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-529825 | 200 µg Ab; 10 µg BP | $361.00 | |||
MOG Antibody (D-2): m-IgGκ BP-HRP Bundle | sc-522850 | 200 µg Ab, 40 µg BP | $361.00 | |||
MOG Antibody (D-2): m-IgG1 BP-HRP Bundle | sc-543708 | 200 µg Ab; 20 µg BP | $361.00 | |||
MOG Antibody (D-2) AC | sc-376138 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MOG Antibody (D-2) HRP | sc-376138 HRP | 200 µg/ml | $322.00 | |||
MOG Antibody (D-2) FITC | sc-376138 FITC | 200 µg/ml | $336.00 | |||
MOG Antibody (D-2) PE | sc-376138 PE | 200 µg/ml | $349.00 | |||
MOG Antibody (D-2) Alexa Fluor® 488 | sc-376138 AF488 | 200 µg/ml | $364.00 | |||
MOG Antibody (D-2) Alexa Fluor® 546 | sc-376138 AF546 | 200 µg/ml | $364.00 | |||
MOG Antibody (D-2) Alexa Fluor® 594 | sc-376138 AF594 | 200 µg/ml | $364.00 | |||
MOG Antibody (D-2) Alexa Fluor® 647 | sc-376138 AF647 | 200 µg/ml | $364.00 | |||
MOG Antibody (D-2) Alexa Fluor® 680 | sc-376138 AF680 | 200 µg/ml | $364.00 | |||
MOG Antibody (D-2) Alexa Fluor® 790 | sc-376138 AF790 | 200 µg/ml | $364.00 | |||
MOG Antibody (D-2) B | sc-376138 B | 200 µg/ml | $326.00 | |||
MOG (D-2) Neutralizing Peptide | sc-376138 P | 100 µg/0.5 ml | $69.00 |