MNS1 Activators
MNS1 Activators are a subset of chemical compounds that indirectly amplify the functional activity of MNS1 through specific intracellular signaling cascades. Compounds such as Forskolin and Dibutyryl-cAMP directly engage the cAMP pathway by either activating adenylate cyclase or mimicking cAMP, thus leading to the activation of PKA. PKA, in turn, phosphorylates various substrates, which may include MNS1, enhancing its activity within its specific signaling pathways. Similarly, IBMX and Rolipram prevent the degradation of cAMP, maintaining the activation of PKA and thereby promoting the phosphorylation and potential enhancement of MNS1 function. PGE2 also heightens cAMP levels via its G-protein-coupled receptors, indirectly leading to the activation of PKA, which could then act on MNS1. Moreover, calcium ionophores like Ionomycin and A23187 increase intracellular calcium, which could potentially activate calcium-dependent kinases that phosphorylate and activate MNS1.
Further elaborating on the activation mechanisms, Sildenafil Citrate and Tadalafil, by inhibiting phosphodiesterase 5, preserve cGMP levels, which can influence cAMP-dependent pathways, indirectly leading to the activation of PKA and subsequent phosphorylation of MNS1. ZM 241385 antagonizes adenosine receptors, which may prevent cAMP downregulation, subsequently promoting MNS1 activation via PKA signaling. Chelerythrine Chloride, as a PKC inhibitor, may shift the balance towards PKA-dependent pathways, enhancing MNS1 activity. Lastly, Epigallocatechin Gallate, by inhibiting various protein kinases, could facilitate a redirection of signaling pathways towards those that activate MNS1, possibly through PKA-dependent mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate MNS1, thereby enhancing MNS1's activity in its specific pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, preventing the breakdown of cAMP. This leads to sustained PKA activity, which can enhance MNS1 function by phosphorylation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its G-protein coupled receptors, leading to increased intracellular cAMP levels, which in turn could activate PKA that may phosphorylate MNS1, enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. MNS1, if regulated by calcium-dependent pathways, would have its function enhanced as a result of ionomycin's action. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels, similar to ionomycin, and could enhance MNS1's activity if MNS1 is involved in calcium-dependent signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. This activation may result in phosphorylation of MNS1, thus enhancing its activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits cAMP-specific phosphodiesterase 4, leading to increased levels of cAMP and subsequent activation of PKA. PKA-mediated phosphorylation could enhance the activity of MNS1. | ||||||
ZM 241385 | 139180-30-6 | sc-361421 sc-361421A | 5 mg 25 mg | $90.00 $349.00 | 1 | |
ZM 241385 is an adenosine receptor antagonist that could prevent the downregulation of cAMP, thereby indirectly promoting the activation of PKA and subsequent phosphorylation of MNS1. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine is a potent inhibitor of protein kinase C (PKC). Inhibition of PKC can shift the balance of cellular signaling towards PKA-dependent pathways, potentially enhancing MNS1 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This polyphenol inhibits several protein kinases, which could lead to a shift in signaling pathways that favor the activation of MNS1 through alternative pathways such as those dependent on PKA. | ||||||