Date published: 2025-12-24

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MMP-20 Inhibitors

MMP-20 inhibitors belong to a distinct chemical class that exerts their influence on a specific enzyme called matrix metalloproteinase-20 (MMP-20). These inhibitors are designed to modulate the activity of MMP-20, a member of the matrix metalloproteinase family, which is responsible for its unique role in enzymatic degradation of various components within the extracellular matrix. MMP-20 is notably involved in the regulation of tissue remodeling and homeostasis through its ability to break down extracellular matrix molecules such as collagen, gelatin, and other substrates. The inhibitors of MMP-20 typically operate by binding to the active site of the enzyme, thereby disrupting its catalytic function and impeding the normal progression of enzymatic reactions. This inhibition mechanism can have implications for the dynamic balance of extracellular matrix turnover, affecting processes like tissue development, cellular migration, and structural maintenance. By specifically targeting MMP-20, these inhibitors offer a nuanced approach to potentially modulate extracellular matrix dynamics, though further research is required to fully comprehend their mechanistic intricacies and broader biological implications.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

NNGH

161314-17-6sc-222075
5 mg
$95.00
2
(1)

NNGH (CAS 161314-17-6) is a chemical compound known for its role as an MMP-20 inhibitor, exhibiting modulation of specific enzyme activity

Marimastat

154039-60-8sc-202223
sc-202223A
sc-202223B
sc-202223C
sc-202223E
5 mg
10 mg
25 mg
50 mg
400 mg
$165.00
$214.00
$396.00
$617.00
$4804.00
19
(1)

A broad-spectrum MMP inhibitor that can bind to the active site of MMPs, including potentially MMP-20, preventing the breakdown of substrate.

GM 6001

142880-36-2sc-203979
sc-203979A
1 mg
5 mg
$75.00
$265.00
55
(1)

A synthetic inhibitor known for its broad specificity towards MMPs, likely inhibiting MMP-20 by binding to its zinc-binding site.

Batimastat

130370-60-4sc-203833
sc-203833A
1 mg
10 mg
$175.00
$370.00
24
(1)

A synthetic peptide mimetic, inhibits MMPs by chelating the zinc ion in the active site, possibly affecting MMP-20.

Doxycycline-d6

564-25-0 unlabeledsc-218274
1 mg
$16500.00
(0)

While primarily an antibiotic, it has been shown to inhibit MMPs non-selectively and could impact MMP-20 activity through metal chelation.

PD 166866

192705-79-6sc-208154
5 mg
$300.00
1
(0)

A hydroxamate-based MMP inhibitor, targets multiple MMPs by binding to the metal ion in the enzyme's active site, likely including MMP-20.

SB-3CT

292605-14-2sc-205847
sc-205847A
1 mg
5 mg
$100.00
$380.00
15
(1)

A selective inhibitor of MMP-2 and MMP-9 that could also extend its inhibitory effects to MMP-20 through mechanism-based inhibition.

Andrographolide

5508-58-7sc-205594
sc-205594A
50 mg
100 mg
$15.00
$39.00
7
(1)

A labdane diterpenoid known for its anti-inflammatory properties, potentially inhibiting MMP-20 by interfering with its expression or activation.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

A natural compound from turmeric, has been shown to downregulate MMP expression and could indirectly inhibit MMP-20 activity by altering signaling pathways.