Molecular structure of NNGH, CAS Number: 161314-17-6
NNGH (CAS 161314-17-6)
See product citations (2)
Alternate Names:
MMP-3 Inhibitor II;BML-205, N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
Application:
NNGH is a potent and cell-permeable inhibitor of MMP-3
CAS Number:
161314-17-6
Purity:
≥98%
Molecular Weight:
316.37
Molecular Formula:
C13H20N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NNGH is a cell-permeable and potent inhibitor of MMP-3. NNGH binds to the active site of enzymes and inhibits their activity. It is thought to bind to the enzyme′s active site by forming a covalent bond with the enzyme′s active site residues. NNGH also binds to proteins and other ligands, forming a non-covalent bond. The binding of NNGH to proteins and other ligands is thought to be mediated by hydrogen bonding and van der Waals forces.
NNGH (CAS 161314-17-6) References
- Inhibition of matrix metalloproteinases prevents the synthesis of insulin-like growth factor binding protein-1 during decidualization in the baboon. | Strakova, Z., et al. 2003. Endocrinology. 144: 5339-46. PMID: 12960035
- Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. | Kim, YS., et al. 2005. J Neurosci. 25: 3701-11. PMID: 15814801
- Catalytic domain of MMP20 (Enamelysin) - the NMR structure of a new matrix metalloproteinase. | Arendt, Y., et al. 2007. FEBS Lett. 581: 4723-6. PMID: 17869250
- Macrophages regulate tumor necrosis factor-alpha expression in adipocytes through the secretion of matrix metalloproteinase-3. | Unoki, H., et al. 2008. Int J Obes (Lond). 32: 902-11. PMID: 18283281
- Mesenchymal stem cells support dorsal root ganglion neurons survival by inhibiting the metalloproteinase pathway. | Scuteri, A., et al. 2011. Neuroscience. 172: 12-9. PMID: 21044661
- Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism. | Christianson, CA., et al. 2012. Neuroscience. 200: 199-210. PMID: 22056600
- MMP-3 provokes CTGF/CCN2 production independently of protease activity and dependently on dynamin-related endocytosis, which contributes to human dental pulp cell migration. | Muromachi, K., et al. 2012. J Cell Biochem. 113: 1348-58. PMID: 22134873
- PTX3 controls activation of matrix metalloproteinase 1 and apoptosis in conjunctivochalasis fibroblasts. | Guo, P., et al. 2012. Invest Ophthalmol Vis Sci. 53: 3414-23. PMID: 22511625
- Microplate fluorescence protease assays test the inhibition of select North American snake venoms' activities with an anti-proteinase library. | Price, JA. 2015. Toxicon. 103: 145-54. PMID: 26130521
- MMP3 activity rather than cortical stiffness determines NHE1-dependent invasiveness of melanoma cells. | Keurhorst, D., et al. 2019. Cancer Cell Int. 19: 285. PMID: 31728131
- Halting Tumor Progression via Novel Non-Hydroxamate Triazole-Based Mannich Bases MMP-2/9 Inhibitors; Design, Microwave-Assisted Synthesis, and Biological Evaluation. | Albelwi, FF., et al. 2021. Int J Mol Sci. 22: PMID: 34638665
- Targeting the interplay between MMP-2, CA II and VEGFR-2 via new sulfonamide-tethered isomeric triazole hybrids; Microwave-assisted synthesis, computational studies and evaluation. | Reda Aouad, M., et al. 2022. Bioorg Chem. 124: 105816. PMID: 35489270
- Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. | MacPherson, LJ., et al. 1997. J Med Chem. 40: 2525-32. PMID: 9258358
Inhibitor of:
ADAM, MMP-1, MMP-10, MMP-12, MMP-13, MMP-2, MMP-20, MMP-3, MMP-7, MMP-8, MMP-9, and MT-MMP-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NNGH, 5 mg | sc-222075 | 5 mg | $95.00 |