NNGH is a cell-permeable and potent inhibitor of MMP-3. Alternate names include MMP-3 Inhibitor II and N-Isobutyl-N-(4-methoxyphenylsufonyl)-glycylhydroxamic Acid. NNGH may also demonstrate inhibition of MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 (metalloelastase), MMP-13, MT-MMP-1 (MMP-14), and MMP-20.
1. MacPherson, L.J., et al. 1997. J. Med. Chem. 40: 2525-2532. PMID: 9258358
Soluble in DMSO (30 mg/ml), and 100% ethanol (8 mg/ml).
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Choi et alChoi et al. (PubMed ID 25536219) found that MMP3 inhibitor, NNGH, significantly reduced mitochondrial ROS and Nox1 induction in N27 cells. -SCBT Publication Review
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