mMGL Activators
mMGL Activators encompass a range of chemical compounds that indirectly augment the functional activity of mMGL through various signaling pathways. For instance, URB602 and JZL184 serve as mMGL inhibitors which, by increasing 2-AG levels, indirectly potentiate cannabinoid receptor signaling pathways regulated by mMGL. The presence of Sulfonyl Fluoride and SA-57, which target other serine hydrolases and ABHD6 respectively, leads to an accumulation of lipid substrates, potentially enhancing mMGL's role in modulating these lipid signaling pathways. Similarly, compounds like PF-3845 and Orlistat, by inhibiting FAAH and gastrointestinal lipases, respectively, may indirectly alter the endocannabinoid system and lipid signaling processes, thereby impacting mMGL activity. The CB1 receptor antagonists, Rimonabant and AM251, might inadvertently promote mMGL's function by causing a compensatory rise in endocannabinoid levels.
Furthermore, the lipid signaling landscape within which mMGL operates can be indirectly influenced by the actions of Tetrahydrolipstatin, MK-886, WWL70, and Palmitoylisoproterenol. Tetrahydrolipstatin's inhibition of lipases may affect mMGL's lipid signaling pathways, while MK-886's action on FLAP has potential repercussions for leukotriene-mediated lipid.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate target proteins, potentially enhancing the lipase activity of mMGL. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP degradation, IBMX indirectly increases PKA activity, which may result in the phosphorylation and activation of mMGL. | ||||||
Palmitoylethanolamide | 544-31-0 | sc-202754 sc-202754A sc-202754B sc-202754C sc-202754D | 10 mg 50 mg 500 mg 1 g 10 g | $80.00 $243.00 $2091.00 $3339.00 $16657.00 | ||
PEA is an endogenous fatty acid amide that can enhance the activity of lipid processing enzymes such as mMGL. PEA's action might be due to its role as a substrate mimic or allosteric modulator of mMGL. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $90.00 $194.00 | 1 | |
OEA is another endogenous fatty acid amide that like PEA, can serve as a substrate mimic or allosteric modulator, potentially enhancing the hydrolytic activity of mMGL on lipid substrates. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine can inhibit a variety of enzymes and has been shown to increase the levels of endocannabinoids, which may lead to secondary enhancement of mMGL activity due to increased substrate availability. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is a vanilloid compound that can modulate lipid signaling pathways. By affecting the endocannabinoid system, it may indirectly increase the activity of enzymes like mMGL that are involved in lipid metabolism. | ||||||
JZL184 | 1101854-58-3 | sc-224031 sc-224031A sc-224031B | 5 mg 10 mg 50 mg | $44.00 $84.00 $306.00 | ||
JZL184 is a potent inhibitor of MAGL, and its administration has been shown to elevate brain monoacylglycerol levels. This could lead to an indirect increase in mMGL activity as the system attempts to regulate lipid signaling. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $203.00 $611.00 | 24 | |
GW4869 is a neutral sphingomyelinase inhibitor that can alter the balance of lipid signaling molecules, potentially resulting in enhanced mMGL activity as part of the cellular lipid metabolism regulatory response. | ||||||