MLF1IP Activators
MLF1IP, known scientifically as CENPU, is a protein encoded by the MLF1IP gene in humans and plays a pivotal role in the proper segregation of chromosomes during cell division. This protein is an integral component of the kinetochore complex, which is essential for the attachment of chromosomes to the spindle fibers, ensuring accurate chromosome alignment and distribution to daughter cells in mitosis. The regulation of MLF1IP expression is a highly orchestrated process, influenced by a myriad of intracellular and extracellular factors that respond to the cell's needs throughout the cell cycle. Given its critical function in cell division, the expression of MLF1IP is precisely timed; it typically peaks during the G2/M phase of the cell cycle, which is the period just before the cell divides. This suggests that factors promoting cell division may also be involved in the regulation of MLF1IP expression.
A variety of chemical compounds have been identified that can potentially act as activators of MLF1IP expression, although their effects can vary based on the cellular context and the current state of the cell. Retinoic acid, a metabolite of vitamin A, is known to play a role in cell differentiation and may sequentially trigger the upregulation of MLF1IP. Histone deacetylase inhibitors, such as Trichostatin A and Sodium butyrate, can alter chromatin structure, potentially leading to an increase in MLF1IP transcription. Forskolin, which elevates cAMP levels, may activate protein kinase A and subsequent downstream pathways that stimulate the expression of MLF1IP. Compounds like Epigallocatechin gallate (EGCG), found abundantly in green tea, can provoke an antioxidant response that may lead to the upregulation of various genes, including MLF1IP. Phorbol esters, such as Phorbol 12-myristate 13-acetate (PMA), are known to activate protein kinase C, which could result in enhanced transcription of MLF1IP. It's important to note that the precise mechanisms by which these activators increase MLF1IP expression are complex and can involve multiple cellular signaling pathways and transcriptional regulation systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can initiate differentiation by activating its receptors, which may sequentially trigger the upregulation of MLF1IP in certain cell types related to growth and development processes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent can reactivate silenced genes by DNA demethylation. It may specifically promote the expression of MLF1IP by removing methyl groups from its gene promoter. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A can enhance transcription of genes by increasing histone acetylation. This may include stimulating the expression of MLF1IP by altering the accessibility of its genomic region. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, by inhibiting deacetylation, can create a favorable environment for transcription factors to increase the expression of MLF1IP. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP, which may activate a protein kinase A (PKA)-dependent pathway, leading to the enhanced expression of genes including MLF1IP. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit GSK-3, potentially stimulating the Wnt/β-catenin pathway and leading to the upregulation of downstream targets like MLF1IP. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate may stimulate antioxidant response elements within gene promoters, which could lead to increased expression of MLF1IP in response to oxidative stress. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is known to activate protein kinase C, which can lead to the phosphorylation of transcription factors, potentially resulting in the increased transcription of MLF1IP. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone may upregulate gene expression by binding to glucocorticoid receptors, which could enhance the transcription of MLF1IP as part of a stress response. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates into DNA and can initiate a cellular response to DNA damage, which may include the upregulation of MLF1IP as part of the DNA repair machinery. | ||||||