MKP-1 Inhibitors
Items 1 to 10 of 13 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide has been shown to suppress MKP-1 expression, potentially by inhibiting the activation of NF-kB and AP-1 transcription factors. | ||||||
Sanguinarine chloride | 5578-73-4 | sc-202800 | 5 mg | $184.00 | 4 | |
Sanguinarine chloride exhibits unique properties as an MKP-1 inhibitor, engaging in selective binding with phosphatase enzymes. Its structural conformation allows for specific interactions that modulate signaling pathways, influencing cellular responses. The compound's ability to form stable complexes with target proteins enhances its efficacy, while its amphiphilic nature promotes interactions with lipid membranes, facilitating cellular entry and subsequent biochemical effects. This dynamic behavior underscores its role in cellular regulation. | ||||||
NSC 95397 | 93718-83-3 | sc-203654 sc-203654A | 10 mg 50 mg | $250.00 $830.00 | 9 | |
NSC 95397 functions as an MKP-1 inhibitor, characterized by its ability to disrupt phosphatase activity through competitive binding. Its unique molecular architecture enables it to engage in specific hydrogen bonding and hydrophobic interactions, influencing downstream signaling cascades. The compound's reactivity as an acid halide allows for the formation of covalent adducts with nucleophilic residues, enhancing its specificity and potency in modulating cellular processes. This intricate interplay of interactions highlights its role in biochemical regulation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone can reduce MKP-1 expression in certain cells. It may act by modulating glucocorticoid receptor signaling which intersects with MAPK pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that may indirectly down-regulate MKP-1 by affecting its upstream pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. Given the relationship between JNK and MKP-1, inhibiting JNK can modulate MKP-1 levels. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor which might decrease MKP-1 expression by inhibiting PI3K-Akt pathway that regulates MKP-1. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib, a kinase inhibitor, may suppress MKP-1 expression by targeting multiple kinases that are upstream regulators of MKP-1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an MEK inhibitor which might down-regulate MKP-1 expression by affecting the ERK pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may down-regulate MKP-1 expression by modulating NF-kB and AP-1 transcription factors, which are involved in MKP-1 regulation. | ||||||