Mitoferrin 2 Activators
Mitoferrin 2 Activators primarily include molecules involved in iron supply (Iron (II) sulfate, Hemin), TCA cycle intermediates (Succinic acid, Pyruvate), electron transport chain inhibitors (Sodium azide, Antimycin A), nitric oxide donors (SNAP, Nitroprusside), iron chelators (Desferrioxamine, Deferoxamine), and hydrogen sulfide donors (Sodium hydrosulfide, Sodium sulfide). Iron (II) sulfate and Hemin provide the divalent iron ions that Mitoferrin 2 requires for its iron transport function, thus enhancing its activity. Succinic acid and Pyruvate, as TCA cycle intermediates, increase the demand for iron in the mitochondria for cytochromes and Fe-S cluster synthesis, thereby enhancing Mitoferrin 2 activity by increasing the need for its iron transport function.
Sodium azide and Antimycin A, by inhibiting complex IV and III of the electron transport chain respectively, stimulate the need for iron in the mitochondria for heme synthesis. This increased demand for mitochondrial iron enhances the activity of Mitoferrin 2 by promoting its iron transport function. Similarly, nitric oxide donors like SNAP and Nitroprusside induce cellular iron deficiency, which raises the need for iron import into mitochondria to maintain iron homeostasis, thereby enhancing Mitoferrin 2 activity. Iron chelators such as Desferrioxamine and Deferoxamine also operate on the principle of induced iron deficiency, leading to an increased need for Mitoferrin 2-mediated iron import into mitochondria. Lastly, hydrogen sulfide donors like Sodium hydrosulfide and Sodium sulfide can bind to and inhibit Fe-S clusters. This inhibition increases the demand for new Fe-S cluster synthesis, which indirectly enhances the activity of Mitoferrin 2 by requiring more iron transport into the mitochondria.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ferrous Sulfate (Iron II Sulfate) Heptahydrate | 7782-63-0 | sc-211505 sc-211505A | 250 g 500 g | $73.00 $109.00 | ||
Iron (II) sulfate supplies the divalent iron ions that Mitoferrin 2 requires to transport iron into mitochondria. With more available iron, Mitoferrin 2 can perform more iron transport cycles, enhancing its activity. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $45.00 $75.00 $133.00 | ||
Succinic acid is a key intermediate in the TCA cycle. By boosting TCA cycle activity, succinic acid can increase the demand for iron in the mitochondria for cytochromes and Fe-S cluster synthesis, which can enhance Mitoferrin 2 activity. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Sodium azide is an inhibitor of cytochrome c oxidase (complex IV of the electron transport chain). Inhibition of complex IV can increase the demand for iron in the mitochondria for heme synthesis, which can enhance Mitoferrin 2 activity. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $41.00 $96.00 | ||
Pyruvate is a key intermediate in glycolysis and can be converted into Acetyl-CoA for the TCA cycle. By boosting TCA cycle activity, pyruvate can increase the demand for iron in the mitochondria for cytochromes and Fe-S cluster synthesis, which can enhance Mitoferrin 2 activity. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $74.00 $114.00 $374.00 | 18 | |
The nitric oxide donor SNAP can induce iron deficiency in cells, which can increase the demand for iron import into mitochondria to maintain iron homeostasis, thereby enhancing Mitoferrin 2 activity. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1060.00 $2923.00 $4392.00 $8333.00 | 19 | |
Deferoxamine is an iron chelator. Chelation of iron can induce iron deficiency in cells, which can increase the demand for iron import into mitochondria to maintain iron homeostasis, thereby enhancing Mitoferrin 2 activity. | ||||||
Hemin chloride | 16009-13-5 | sc-202646 sc-202646A sc-202646B | 5 g 10 g 25 g | $102.00 $160.00 $326.00 | 9 | |
Hemin is an iron-containing compound that can induce heme oxygenase, an enzyme that liberates iron from heme. The liberated iron can increase the demand for iron import into mitochondria to maintain iron homeostasis, thereby enhancing Mitoferrin 2 activity. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Nitroprusside is a nitric oxide donor. Nitric oxide can induce iron deficiency in cells, which can increase the demand for iron import into mitochondria to maintain iron homeostasis, thereby enhancing Mitoferrin 2 activity. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A is an inhibitor of complex III of the electron transport chain. Inhibition of complex III can increase the demand for iron in the mitochondria for heme synthesis, which can enhance Mitoferrin 2 activity. | ||||||