Hemin chloride (CAS 16009-13-5)
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Hemin chloride, a heme oxygenase-1 inducer, is a porphyrin complex that is derived from erythrocytes. At a concentration of 20 mM, Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. Hemin chloride has been observed to induce cGMP formation through induction of guanylate cyclase. In rats, Hemin chloride has been noted to stimulate calcium dependent K+ channels along with control of fluid transport and Na+ in the loop of henle. Hemin chloride has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes Hemin chloride demonstrated anti-apoptotic, anti-inflamatory and antioxidant properties. Through reactive oxygen species of ERK-1/2-Elk-1 and NF-kappa Hemin chloride may act to upregulate Egr-1 expression in vascular smooth muscle cells. Hemin chloride has also been used in solution to prepare certain types of Agar medium for the cultivation of distinct bacteria.
Hemin chloride (CAS 16009-13-5) References
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- Hemin pretreatment ameliorates aspects of the nephropathy induced by mercuric chloride in the rat. | Yoneya, R., et al. 2000. Toxicol Lett. 116: 223-9. PMID: 10996484
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- Hemin induces active chloride secretion in Caco-2 cells. | Uc, A., et al. 2005. Am J Physiol Gastrointest Liver Physiol. 289: G202-8. PMID: 15805100
- Interaction of azide ion with hemin and cytochrome c immobilized on Au and Ag nanoparticles. | Tom, RT. and Pradeep, T. 2005. Langmuir. 21: 11896-902. PMID: 16316130
- Hemin upregulates Egr-1 expression in vascular smooth muscle cells via reactive oxygen species ERK-1/2-Elk-1 and NF-kappaB. | Hasan, RN. and Schafer, AI. 2008. Circ Res. 102: 42-50. PMID: 17967787
- Protective effect of hemin against cadmium-induced testicular damage in rats. | Fouad, AA., et al. 2009. Toxicology. 257: 153-60. PMID: 19150641
- Ostensible enzyme promiscuity: alkene cleavage by peroxidases. | Mutti, FG., et al. 2010. Chemistry. 16: 14142-8. PMID: 20981671
- A novel method to stabilize meat colour: ligand coordinating with hemin. | Zhou, C., et al. 2014. J Food Sci Technol. 51: 1213-7. PMID: 24876659
- Binding of hemin, hematoporphyrin, and protoporphyrin with erythroid spectrin: fluorescence and molecular docking studies. | Das, D., et al. 2015. Eur Biophys J. 44: 171-82. PMID: 25737232
- Hemin enhances differentiation and maturation of cultured regenerated skeletal myotubes. | Funanage, VL., et al. 1989. J Cell Physiol. 141: 591-7. PMID: 2592428
- Studies on hydroperoxide-dependent folic acid degradation by hemin. | Taher, MM. and Lakshmaiah, N. 1987. Arch Biochem Biophys. 257: 100-6. PMID: 2820306
- Induction of Heme oxygenase 1 protects hepatocytes from Isoniazid – Rifampicin induced cell death: an in vitro study. | Bishnu, D., et al. 2016. Trop Gastroenterol. 37: 27-36. PMID: 29668174
- Indirect Quantification of Glyphosate by SERS Using an Incubation Process With Hemin as the Reporter Molecule: A Contribution to Signal Amplification Mechanism. | López-Castaños, KA., et al. 2020. Front Chem. 8: 612076. PMID: 33392153
- Porphyrins ameliorate spinocerebellar ataxia type 36 GGCCTG repeat expansion-mediated cytotoxicity. | Hirayanagi, K., et al. 2021. Neurosci Res. 171: 92-102. PMID: 33705846
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hemin chloride, 5 g | sc-202646 | 5 g | $100.00 | |||
Hemin chloride, 10 g | sc-202646A | 10 g | $157.00 | |||
Hemin chloride, 25 g | sc-202646B | 25 g | $320.00 |