MIST1 Activators
MIST1, also known as BHLHA15, is a transcription factor primarily expressed in secretory cells of exocrine glands, where it plays a pivotal role in regulating the differentiation and function of these cells. Its function is essential for the development and maintenance of exocrine tissues, including pancreatic acinar cells, gastric chief cells, and salivary gland acinar cells. MIST1 orchestrates various cellular processes crucial for secretory cell biology, such as the synthesis and secretion of digestive enzymes, exocytosis, protein synthesis, and trafficking. Moreover, MIST1 is involved in establishing and maintaining cell polarity and morphology, which are critical for the proper formation and functioning of secretory glands. Dysfunction of MIST1 can lead to impaired differentiation and maturation of secretory cells, disruption of glandular homeostasis, and the development of pathological conditions.
Activation of MIST1 involves complex regulatory mechanisms that coordinate its transcriptional activity and post-translational modifications. Several signaling pathways contribute to the activation of MIST1, including those mediated by growth factors, hormones, and cell-cell interactions. These pathways converge to regulate the expression and activity of transcriptional co-factors and modulators that interact with MIST1 to enhance its transcriptional activity. Additionally, post-translational modifications such as phosphorylation, acetylation, and sumoylation can regulate MIST1 function by modulating its stability, DNA-binding affinity, and interaction with other proteins. Furthermore, the spatial and temporal regulation of MIST1 expression and activity by upstream signaling molecules and transcriptional regulators ensures proper secretory cell development and function. Overall, the activation of MIST1 is a tightly regulated process involving multiple signaling pathways and post-translational modifications that govern its transcriptional activity and biological functions in secretory cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. MIST1 is known to be regulated by cAMP, and Forskolin, by enhancing cAMP signaling, directly influences MIST1 activity. The activation of cAMP signaling by Forskolin impacts cellular processes associated with MIST1, including its role in pancreatic acinar cell differentiation and function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), a key regulator of MIST1. By activating PKC, PMA directly influences MIST1 activity. The phosphorylation of MIST1 by activated PKC impacts cellular processes associated with MIST1, including its role in the regulation of acinar cell differentiation and pancreatic function. | ||||||
8-CPT-cAMP | 93882-12-3 | sc-201569 sc-201569A | 20 mg 100 mg | $87.00 $316.00 | 19 | |
8-CPT-cAMP is a cAMP analog that directly activates cAMP-dependent signaling pathways. MIST1 is regulated by cAMP, and the direct activation of cAMP signaling by 8-CPT-cAMP influences MIST1 activity. This modulation affects cellular processes associated with MIST1, including its role in pancreatic acinar cell differentiation and function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, a histone deacetylase involved in MIST1 regulation. By activating SIRT1, Resveratrol directly influences MIST1 activity. The deacetylation of MIST1 by SIRT1 impacts cellular processes associated with MIST1, including its role in the regulation of acinar cell differentiation and pancreatic function. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), a kinase implicated in MIST1 regulation. By activating AMPK, AICAR directly influences MIST1 activity. The phosphorylation of MIST1 by activated AMPK impacts cellular processes associated with MIST1, including its role in the regulation of acinar cell differentiation and pancreatic function. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone activates the glucocorticoid receptor (GR), which directly influences MIST1. The activated GR modulates MIST1 activity, impacting cellular processes associated with MIST1, including its role in pancreatic acinar cell differentiation and function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates GSK-3β, a kinase implicated in MIST1 regulation. By inhibiting GSK-3β, Lithium chloride indirectly influences MIST1 activity. The inhibition of GSK-3β leads to the stabilization of MIST1, impacting cellular processes associated with MIST1, including its role in pancreatic acinar cell differentiation and function. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 inhibits NF-κB activation, influencing MIST1 regulation. By inhibiting NF-κB, Bay 11-7082 indirectly influences MIST1 activity. The modulation of NF-κB signaling by Bay 11-7082 impacts cellular processes associated with MIST1, including its role in pancreatic acinar cell differentiation and function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 inhibits the TGF-β receptor ALK5, which is implicated in MIST1 regulation. By inhibiting ALK5, SB-431542 indirectly influences MIST1 activity. The modulation of TGF-β signaling by SB-431542 impacts cellular processes associated with MIST1, including its role in pancreatic acinar cell differentiation and function. | ||||||