MIA3 Inhibitors
MIA3 inhibitors belong to a distinctive chemical class that primarily targets the MIA3 protein, also known as transport and Golgi organization 1 homolog (TANGO1). TANGO1 plays a crucial role in the regulation of secretory pathway integrity within cells, particularly in the early stages of protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus. The inhibition of MIA3 aims to modulate this intricate cellular process.
MIA3 itself serves as a crucial component in the formation of large cargo carriers, facilitating the export of bulky proteins from the ER. As a class of inhibitors, MIA3 inhibitors act by disrupting the interactions involving MIA3, thereby impeding its function and subsequently influencing the secretory pathway. This interference in protein trafficking may have far-reaching implications for cellular homeostasis and function.MIA3 inhibitors are often meticulously designed to interact with specific binding sites on the MIA3 protein, hindering its ability to coordinate the assembly of transport carriers. These inhibitors can exhibit diverse chemical structures, ranging from small molecules to more complex entities, depending on the precise molecular interactions targeted within the MIA3 protein. The exploration and development of MIA3 inhibitors represent a promising avenue in cell biology research, shedding light on the intricacies of intracellular transport mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is a lactone antibiotic that disrupts the structure and function of the Golgi apparatus by inhibiting ADP ribosylation factor (ARF), thus indirectly affecting the TANGO pathway. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore antibiotic that disrupts Golgi function by altering intracellular ion concentrations, thereby indirectly affecting the TANGO pathway. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which can indirectly affect intracellular transport mechanisms involved in the TANGO pathway. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main components of microtubules, thus potentially affecting the TANGO pathway. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can disrupt various transport mechanisms, indirectly affecting the TANGO pathway. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filaments and can thereby affect cellular transport processes, potentially influencing the TANGO pathway. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic Acid is an inhibitor of inosine monophosphate dehydrogenase, which can disrupt guanine nucleotide biosynthesis, potentially affecting protein trafficking and the TANGO pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of phosphoinositide 3-kinases, which can disrupt intracellular signal transduction and potentially influence the TANGO pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a morpholine derivative and a potent inhibitor of phosphoinositide 3-kinases, which can disrupt intracellular signal transduction and potentially influence the TANGO pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a protein involved in multiple cellular processes including protein synthesis and trafficking, thereby potentially influencing the TANGO pathway. | ||||||