Chemical inhibitors of MGC99813 can affect the protein's function through various mechanisms, each targeting different aspects of cellular regulation. Trichostatin A, by inhibiting histone deacetylases, can alter gene expression patterns, which may lead to changes in the acetylation state of proteins that interact with or regulate MGC99813, possibly maintaining MGC99813 in a hyperacetylated and less active state. Rapamycin, targeting the mTOR pathway, can suppress protein synthesis and cell growth, potentially decreasing the activity or stability of MGC99813 by impeding the function of downstream pathways that MGC99813 may rely on. Similarly, Alsterpaullone disrupts cell cycle progression by inhibiting cyclin-dependent kinases, which could modify the phosphorylation status of proteins in connection with MGC99813, leading to its functional inhibition.
LY294002 and U0126 work by blocking specific signaling pathways that may be crucial for the activation or function of MGC99813. LY294002 prevents PI3K/Akt pathway signaling, which could inhibit MGC99813 if its activation or stability is dependent on this pathway. U0126 suppresses the MAPK/ERK pathway by inhibiting MEK, potentially reducing the phosphorylation and activity of MGC99813 if it is regulated by this pathway. SB431542 hinders TGF-β signaling, which could also reduce the function or expression of MGC99813 if it is TGF-β dependent. Bortezomib, by inhibiting the proteasome, can lead to the accumulation of misfolded proteins and a general stress response, which might indirectly inhibit the function of MGC99813. Sorafenib and Imatinib, both tyrosine kinase inhibitors, target different kinases that could be involved in MGC99813 regulation. Sorafenib inhibits Raf kinases, which are part of the MAPK/ERK pathway, while Imatinib targets kinases such as BCR-ABL, c-Kit, and PDGFR, which, if involved in regulating MGC99813, could reduce its activity. ZM-447439, an Aurora kinase inhibitor, could disrupt cell cycle progression and processes essential for MGC99813's function. Lastly, Thapsigargin, by increasing cytosolic calcium levels through SERCA pump inhibition, could affect MGC99813 if its function is calcium-dependent, and PD98059, another MEK inhibitor, would prevent the activation of ERK and possibly inhibit the function of MGC99813.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can upregulate histone acetylation, leading to altered gene expression. If MGC99813 is regulated by acetylation status, Trichostatin A would inhibit its function by maintaining a hyperacetylated state that alters its interaction with DNA or other proteins. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that impedes the mTOR pathway, which is crucial for protein synthesis and cell growth. Inhibition of mTOR can decrease the activity of downstream effectors that may be necessary for MGC99813 function or stability. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that may disrupt cell cycle progression. By hindering CDKs, it can influence the phosphorylation state of proteins that interact with or regulate MGC99813, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that blocks the PI3K/Akt signaling pathway. If MGC99813 relies on PI3K/Akt signaling for its activation or stability, LY294002 would inhibit its function by preventing signal transduction. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, a kinase within the MAPK/ERK pathway. MEK inhibition results in reduced ERK phosphorylation, which could inhibit MGC99813 if it depends on the MAPK/ERK pathway for its activation or function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a selective inhibitor of the TGF-β receptor type I. It prevents TGF-β signaling which could inhibit MGC99813 if it requires TGF-β signaling for its function or expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can lead to the accumulation of misfolded proteins, potentially disrupting cellular functions that MGC99813 is part of by causing a general stress response that can inhibit its function. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a tyrosine kinase inhibitor with activity against Raf kinases. Inhibition of Raf kinases can affect the MAPK/ERK pathway, possibly leading to the inhibition of MGC99813 if it relies on this pathway. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a tyrosine kinase inhibitor that primarily targets BCR-ABL, c-Kit, and PDGFR. If MGC99813 is involved in signaling pathways that include these kinases, its activity could be inhibited by Imatinib. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. Aurora kinases play a role in cell cycle progression; thus, inhibiting them could disrupt processes that are essential for the function of MGC99813. |