MEIKIN Inhibitors
MEIKIN inhibitors play a crucial role in the regulation of meiotic cell division by specifically targeting the processes and proteins that interact with MEIKIN to ensure proper kinetochore function, chromosome alignment, and segregation. These inhibitors include chemicals that destabilize microtubule dynamics, thus preventing the correct assembly of the spindle apparatus, which is essential for MEIKIN to perform its role in chromosome segregation. By stabilizing microtubules to an extreme or depolymerizing them altogether, the dynamic balance necessary for kinetochore-microtubule attachment is disturbed, leading to an indirect inhibition of MEIKIN, as its function is deeply embedded in the structural integrity of the spindle. Additionally, inhibitors that target specific kinases such as Aurora B and Plk1 also play a significant role by preventing the phosphorylation of kinetochore proteins, which is a prerequisite for MEIKIN localization and activity during meiotic divisions.
Further indirect inhibition of MEIKIN is achieved through the use of chemicals that interfere with spindle checkpoint signaling and centrosome functions. Inhibitors that block the activity of essential regulatory kinases such as Mps1, or disrupt the function of components like BubR1, culminate in the inability to maintain proper spindle checkpoint control, thereby affecting MEIKIN's role in the meiotic process. Cyclin-dependent kinase inhibitors that arrest the cell cycle also indirectly affect MEIKIN as they prevent cells from entering meiosis, the stage where MEIKIN is active.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
An Eg5 (kinesin-5) inhibitor that disrupts microtubule dynamics, leading to improper spindle assembly, which indirectly inhibits MEIKIN's role in chromosome segregation during meiosis. | ||||||
Reversine | 656820-32-5 | sc-203236 | 5 mg | $217.00 | 13 | |
An Aurora B kinase inhibitor that prevents the correct localization of MEIKIN to the kinetochore by disrupting the phosphorylation status of kinetochore proteins. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
A microtubule stabilizer that impairs the dynamic changes required for proper kinetochore-microtubule attachment, indirectly affecting MEIKIN's function in chromatid alignment and segregation. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
A microtubule depolymerizing agent that leads to spindle disassembly, thereby affecting MEIKIN's ability to function in meiotic spindle checkpoint signaling. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
An inhibitor of Aurora B kinase which is essential for correcting kinetochore-microtubule attachment errors, thereby impacting MEIKIN's kinetochore function during meiosis. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
A potent Plk1 inhibitor that disrupts spindle assembly and kinetochore function, thereby indirectly affecting MEIKIN's role in the proper alignment and segregation of chromosomes. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor that disrupts the phosphorylation of kinetochore proteins, which is necessary for MEIKIN localization and function during meiotic cell division. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
A kinesin Eg5 inhibitor that blocks spindle pole separation, leading to spindle checkpoint activation and indirectly interfering with MEIKIN function in meiosis. | ||||||
AZ 3146 | 1124329-14-1 | sc-361114 sc-361114A | 10 mg 50 mg | $214.00 $887.00 | 7 | |
A Mps1 inhibitor that prevents the centrosome from duplicating and spindle checkpoint signaling, thereby indirectly inhibiting MEIKIN's role in meiotic chromosome segregation. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
A cyclin-dependent kinase (CDK) inhibitor that halts cell cycle progression, indirectly affecting MEIKIN's function by preventing meiotic entry where it is active. | ||||||