MEGF11 Activators
MEGF11 Activators are a range of chemical compounds that enhance the functional activity of MEGF11 through various signaling pathways and cellular processes. Forskolin and Rolipram, by increasing cAMP levels, activate PKA, which can indirectly boost MEGF11's role in cell-cell communication and adhesion. This enhancement is facilitated through the modulation of signaling pathways where MEGF11 acts as a crucial mediator, particularly in processes involving cell surface interactions. Similarly, EGCG, through its kinase inhibitory action, can indirectly support MEGF11's functionality in cell adhesion and communication by modulating the kinase-mediated signaling pathways in which MEGF11 is a key component. Ionomycin, by increasing intracellular calcium levels, and PMA, through the activation of PKC, further contribute to enhancing MEGF11's role in cellular interactions by affecting calcium-dependent and PKC-mediated signaling cascades, respectively.
Additionally, SB203580, which targets p38 MAPK pathway, plays a significant role in shifting the balance of cell signaling involved in adhesion and communication, thus indirectly enhancing MEGF11's involvement in these processes. Trichostatin A (TSA), by altering gene expression patterns, and Sildenafil, through elevating cAMP/cGMP levels, further support MEGF11's functional enhancement. TSA achieves this by influencing the expression of genes in signaling pathways where MEGF11 functions, while Sildenafil enhances PKA and PKG activity, impacting the signaling pathways involved in adhesion and communication. Furthermore, Resveratrol, acting through SIRT1 to modulate protein acetylation and gene expression, and BAY 11-7082, by inhibiting NF-κB activation, modify cellular signaling dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP activates PKA, which can phosphorylate targets involved in cell signaling pathways. This may enhance MEGF11's role in cell-cell communication and adhesion by modulating signaling pathways where MEGF11 is a crucial mediator. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, leading to increased cAMP levels. This can activate PKA, which may enhance MEGF11's function by influencing signaling cascades that regulate cell adhesion and communication, processes in which MEGF11 is implicated due to its role in cell surface interactions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits various protein kinases. By inhibiting these kinases, EGCG could indirectly enhance MEGF11's role in cell signaling related to adhesion and communication, as it may modulate kinase-mediated signaling pathways where MEGF11 functions as a key component. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, activating calcium-dependent signaling pathways. This can enhance MEGF11's role in cell-cell communication and adhesion by modulating calcium-dependent signaling cascades where MEGF11 is involved in mediating cellular interactions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC). PKC activation can influence cell adhesion and communication signaling pathways. This may enhance MEGF11's role in these processes by modulating the signaling cascades that MEGF11 is part of, particularly those involved in cellular interactions and surface communication. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK. By influencing cell signaling pathways, particularly those involved in cell adhesion and communication, it may enhance MEGF11's role in these processes, as MEGF11 is a mediator in cell surface interactions and signaling networks related to cellular communication. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase inhibitor. By altering gene expression patterns, TSA can affect cell signaling pathways, potentially enhancing MEGF11's role in cell-cell communication and adhesion, as it may influence the expression of genes involved in the signaling pathways where MEGF11 functions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a NAD+-dependent deacetylase. By modulating protein acetylation and gene expression, it can influence cell adhesion and communication pathways. This may enhance MEGF11's role in these processes, particularly in signaling networks where MEGF11 is involved in cellular interactions. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation by blocking IκBα phosphorylation. This can shift cellular signaling dynamics, potentially enhancing MEGF11's role in cell adhesion and communication by influencing the signaling pathways where MEGF11 functions, particularly those involved in cellular interactions. | ||||||