Date published: 2026-2-14

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MEF-2D Inhibitors

MEF-2D Inhibitors are a class of chemical compounds specifically designed to inhibit the activity of Myocyte Enhancer Factor 2D (MEF-2D), a member of the MEF2 family of transcription factors. MEF-2D is involved in regulating gene expression related to a variety of cellular processes, including muscle development, neuronal differentiation, and immune responses. By binding to DNA at specific sites, MEF-2D controls the transcription of genes that are critical for cell differentiation and function. The inhibition of MEF-2D can therefore lead to alterations in gene expression, providing a powerful tool for researchers to study the regulatory networks governed by this transcription factor.

The study of MEF-2D Inhibitors has opened new avenues for understanding the role of transcription factors in cell fate determination and the broader implications of transcriptional regulation in various biological processes. By inhibiting MEF-2D, researchers can investigate the downstream effects on target gene expression, shedding light on how MEF-2D contributes to cellular development and function. This is particularly relevant in the context of understanding how transcription factors like MEF-2D interact with other proteins and signaling pathways to orchestrate complex cellular responses. Additionally, MEF-2D Inhibitors provide a valuable tool for exploring the specific roles of MEF-2D in different tissue types, such as muscle and neurons, where it plays a critical role in maintaining proper function and development. Overall, MEF-2D Inhibitors are instrumental in advancing our knowledge of transcriptional regulation and its impact on cellular processes, offering a deeper understanding of the molecular mechanisms that underlie cell differentiation and function.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

KN-93

139298-40-1sc-202199
1 mg
$182.00
25
(1)

KN-93 is a selective inhibitor of CaMKII, a kinase that phosphorylates MEF2. Inhibition of CaMKII activity results in reduced phosphorylation and thus decreased activity of MEF2.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$63.00
$92.00
$250.00
$485.00
$1035.00
$2141.00
69
(5)

Cyclosporin A inhibits calcineurin, which when active can dephosphorylate and activate MEF2. Its inhibition thus prevents MEF2 activation.

H-89 dihydrochloride

130964-39-5sc-3537
sc-3537A
1 mg
10 mg
$94.00
$186.00
71
(2)

H-89 is a potent inhibitor of PKA, which can phosphorylate MEF2. Inhibition of PKA leads to reduced MEF2 phosphorylation and activity.

Valproic Acid

99-66-1sc-213144
10 g
$87.00
9
(1)

Valproic acid, while an HDAC inhibitor, can also exert inhibitory effects on MEF2 by altering the chromatin state and gene expression profiles that could suppress MEF2 activity.

SB-216763

280744-09-4sc-200646
sc-200646A
1 mg
5 mg
$71.00
$202.00
18
(1)

SB 216763 inhibits GSK-3β, which normally phosphorylates MEF2. However, in some contexts, GSK-3β activity may be required for MEF2 activation, so its inhibition could lead to decreased MEF2 activity.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits mTOR, which can influence multiple downstream signaling pathways, including those that may activate MEF2, leading to decreased activity.

Verapamil

52-53-9sc-507373
1 g
$374.00
(0)

Verapamil blocks L-type calcium channels, potentially decreasing intracellular calcium and subsequently inhibiting CaMK, thus reducing MEF2 activation.

GW 9662

22978-25-2sc-202641
5 mg
$70.00
30
(2)

GW9662 antagonizes PPARγ, possibly counteracting the activation effects on MEF2 signaling.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$91.00
$139.00
$374.00
36
(1)

Dexamethasone, a glucocorticoid, can suppress various signaling pathways and alter gene expression, potentially downregulating MEF2 activity.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 selectively inhibits p38 MAPK, which may indirectly influence MEF2 activity by modulating the signaling environment that regulates MEF2.